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• W2038863904 endingPage "364" @default.
• W2038863904 startingPage "356" @default.
• W2038863904 abstract "It has been demonstrated that the activity of the sodium-proton exchanger (NHE-1 isoform) is increased in lymphocytes and other blood cells from patients with essential hypertension. In the present study, we investigated whether an increased level of NHE-1-specific mRNA in lymphocytes from patients with essential hypertension would explain the enhanced transport activity. Twenty-two hypertensive patients and 21 normotensive subjects were studied. Basal cytosolic pH was measured by the pH-sensitive fluorescent probe 2',7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein. Maximal sodium-proton exchange activity was determined by acidifying cell pH and measuring the initial rate of the net sodium-dependent proton efflux driven by an outward proton gradient. The transcript level of NHE-1 was measured by reverse transcription-polymerase chain reaction in comparison with a constitutively expressed reference gene (beta-actin). Intracellular pH was lower in hypertensive patients than normotensive subjects (7.34 +/- 0.01 versus 7.39 +/- 0.01, mean +/- SEM, P < .001). The maximal activity of the sodium-proton exchanger was higher in hypertensive patients than in normotensive subjects (1262 +/- 100 versus 881 +/- 56 mmol/L cells per hour, P < .01). NHE-1 mRNA was increased in hypertensive patients compared with normotensive subjects (ratio of NHE-1 mRNA to beta-actin mRNA, 0.16 +/- 0.01 versus 0.12 +/- 0.02, P < .05). These data suggest that the increased sodium-proton exchange activity in essential hypertension may be related to the de novo synthesis of exchanger protein." @default.
• W2038863904 created "2016-06-24" @default.
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• W2038863904 date "1995-03-01" @default.
• W2038863904 modified "2023-10-14" @default.
• W2038863904 title "Enhanced Na ⁺ -H ⁺ Exchanger Activity and NHE-1 mRNA Expression in Lymphocytes From Patients With Essential Hypertension" @default.
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• W2038863904 doi "https://doi.org/10.1161/01.hyp.25.3.356" @default.
• W2038863904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7875760" @default.
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