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- W2038866475 abstract "Fibronectin (FN) is a multifunctional extracellular matrix glycoprotein, which participates in cell migration and signalling to adhering cells. Due to alternative splicing and post‐translational modifications, different isoforms of FN are generated by a wide variety of cells. T lymphocytes synthesize a surface‐associated isoform of FN, containing the two ‘extradomains’ EDA and EDB. In the present study, we identified gangliosides within the T‐cell membrane as specific binding sites for the N‐terminal 30 kDa fragment of FN. When T cells were activated with anti‐CD3 coated beads, FN, together with the ganglioside GM1, converged at the contact zone. Moreover, endogenous FN was present in the detergent insoluble microdomain. The function of FN in T cells is still under investigation; however, its presence together with gangliosides at the activation site suggests participation in T‐cell signalling." @default.
- W2038866475 created "2016-06-24" @default.
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- W2038866475 date "2005-04-01" @default.
- W2038866475 modified "2023-09-26" @default.
- W2038866475 title "Fibronectin on activated T lymphocytes is bound to gangliosides and is present in detergent insoluble microdomains" @default.
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- W2038866475 doi "https://doi.org/10.1111/j.1440-1711.2005.01318.x" @default.
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