Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038871606> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2038871606 endingPage "571" @default.
- W2038871606 startingPage "568" @default.
- W2038871606 abstract "An in vivo-in vitro model was used to assess the antimalarial activity of PS-15 and its metabolite, WR99210, against Plasmodium falciparum. WR99210, an antifolate triazine compound, was given as a single oral dose of 30 mg/kg to 8 Saimiri sciureus monkeys and, 3 months later, the parent compound, PS-15, was given similarly to the same monkeys. Serum samples were collected at various times after drug administration, serially diluted with control serum, and their antimalarial activity in vitro was determined against the multidrug-resistant K1 isolate of P. falciparum. Serum concentrations of PS-15 and WR99210 were esimated by high performance liquid chromatography. The maximum dilutions of serum that inhibited parasite growth were 20- to 86-fold higher 3 and 6 h after administration of PS-15 than following WR99210 administration. Substantial serum antimalarial activity was observed even at 48 h after medication with PS-15. Serum drug concentrations provided further evidence that PS-15 was absorbed far better from the gastrointestinal tract than WR99210. The substantial and sustained activity of PS-15 suggests that a single dose, or several smaller doses given once a day, should be effective in curing drug-resistant infections of P. falciparum." @default.
- W2038871606 created "2016-06-24" @default.
- W2038871606 creator A5001484726 @default.
- W2038871606 creator A5003204240 @default.
- W2038871606 creator A5072638559 @default.
- W2038871606 date "1996-09-01" @default.
- W2038871606 modified "2023-10-13" @default.
- W2038871606 title "Activity of PS-15 and its metabolite, WR99210, against Plasmodium falciparum in an in vivo-in vitro model" @default.
- W2038871606 cites W1969503178 @default.
- W2038871606 cites W1990074634 @default.
- W2038871606 cites W2020245579 @default.
- W2038871606 cites W2020251171 @default.
- W2038871606 cites W2082765735 @default.
- W2038871606 cites W2104244554 @default.
- W2038871606 cites W2438909226 @default.
- W2038871606 cites W2441279826 @default.
- W2038871606 cites W88514413 @default.
- W2038871606 doi "https://doi.org/10.1016/s0035-9203(96)90326-0" @default.
- W2038871606 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8944276" @default.
- W2038871606 hasPublicationYear "1996" @default.
- W2038871606 type Work @default.
- W2038871606 sameAs 2038871606 @default.
- W2038871606 citedByCount "46" @default.
- W2038871606 countsByYear W20388716062012 @default.
- W2038871606 countsByYear W20388716062014 @default.
- W2038871606 countsByYear W20388716062015 @default.
- W2038871606 countsByYear W20388716062016 @default.
- W2038871606 countsByYear W20388716062017 @default.
- W2038871606 countsByYear W20388716062018 @default.
- W2038871606 countsByYear W20388716062019 @default.
- W2038871606 countsByYear W20388716062020 @default.
- W2038871606 countsByYear W20388716062021 @default.
- W2038871606 countsByYear W20388716062022 @default.
- W2038871606 countsByYear W20388716062023 @default.
- W2038871606 crossrefType "journal-article" @default.
- W2038871606 hasAuthorship W2038871606A5001484726 @default.
- W2038871606 hasAuthorship W2038871606A5003204240 @default.
- W2038871606 hasAuthorship W2038871606A5072638559 @default.
- W2038871606 hasConcept C112705442 @default.
- W2038871606 hasConcept C142724271 @default.
- W2038871606 hasConcept C150903083 @default.
- W2038871606 hasConcept C184112429 @default.
- W2038871606 hasConcept C185592680 @default.
- W2038871606 hasConcept C202751555 @default.
- W2038871606 hasConcept C203014093 @default.
- W2038871606 hasConcept C204787440 @default.
- W2038871606 hasConcept C207001950 @default.
- W2038871606 hasConcept C2777056448 @default.
- W2038871606 hasConcept C2777477808 @default.
- W2038871606 hasConcept C2778048844 @default.
- W2038871606 hasConcept C2778371730 @default.
- W2038871606 hasConcept C2778397455 @default.
- W2038871606 hasConcept C2781059491 @default.
- W2038871606 hasConcept C2781382166 @default.
- W2038871606 hasConcept C55493867 @default.
- W2038871606 hasConcept C71924100 @default.
- W2038871606 hasConcept C86803240 @default.
- W2038871606 hasConcept C98274493 @default.
- W2038871606 hasConceptScore W2038871606C112705442 @default.
- W2038871606 hasConceptScore W2038871606C142724271 @default.
- W2038871606 hasConceptScore W2038871606C150903083 @default.
- W2038871606 hasConceptScore W2038871606C184112429 @default.
- W2038871606 hasConceptScore W2038871606C185592680 @default.
- W2038871606 hasConceptScore W2038871606C202751555 @default.
- W2038871606 hasConceptScore W2038871606C203014093 @default.
- W2038871606 hasConceptScore W2038871606C204787440 @default.
- W2038871606 hasConceptScore W2038871606C207001950 @default.
- W2038871606 hasConceptScore W2038871606C2777056448 @default.
- W2038871606 hasConceptScore W2038871606C2777477808 @default.
- W2038871606 hasConceptScore W2038871606C2778048844 @default.
- W2038871606 hasConceptScore W2038871606C2778371730 @default.
- W2038871606 hasConceptScore W2038871606C2778397455 @default.
- W2038871606 hasConceptScore W2038871606C2781059491 @default.
- W2038871606 hasConceptScore W2038871606C2781382166 @default.
- W2038871606 hasConceptScore W2038871606C55493867 @default.
- W2038871606 hasConceptScore W2038871606C71924100 @default.
- W2038871606 hasConceptScore W2038871606C86803240 @default.
- W2038871606 hasConceptScore W2038871606C98274493 @default.
- W2038871606 hasIssue "5" @default.
- W2038871606 hasLocation W20388716061 @default.
- W2038871606 hasLocation W20388716062 @default.
- W2038871606 hasOpenAccess W2038871606 @default.
- W2038871606 hasPrimaryLocation W20388716061 @default.
- W2038871606 hasRelatedWork W1491964893 @default.
- W2038871606 hasRelatedWork W1998356222 @default.
- W2038871606 hasRelatedWork W2030336508 @default.
- W2038871606 hasRelatedWork W2040155790 @default.
- W2038871606 hasRelatedWork W2056938528 @default.
- W2038871606 hasRelatedWork W2065023395 @default.
- W2038871606 hasRelatedWork W2148177218 @default.
- W2038871606 hasRelatedWork W2436912489 @default.
- W2038871606 hasRelatedWork W2753834235 @default.
- W2038871606 hasRelatedWork W94631600 @default.
- W2038871606 hasVolume "90" @default.
- W2038871606 isParatext "false" @default.
- W2038871606 isRetracted "false" @default.
- W2038871606 magId "2038871606" @default.
- W2038871606 workType "article" @default.