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• W2038874849 abstract "Excess adiposity increases systemic inflammation, which is implicated in various diseases. Physical activity, both forced and voluntary, may reverse the disease risk associated with weight gain from high-fat, high-calorie feeding. PURPOSE: To determine if 8-weeks of aerobic exercise training combined with low-fat feeding reverses changes in monocyte concentration, monocyte TLR2/TLR4 expression, glucose and cholesterol. METHODS: For 12-months, 24 CD-1 mice underwent a pre-treatment phase, consuming either a low-fat (10% kcal from fat) or high-fat (60% kcal from fat) diet ad libitum. Mice were randomly assigned to one of four groups (N=6/group): CN (low-fat chow pre-treatment and study duration, no exercise), V-EX (high-fat pre-treatment, switched to low-fat chow, free access to running wheel 5 days/week), F-EX (high-fat pre-treatment, switched to low-fat chow, forced treadmill running at 22 m-min-1, 60-min/day, 5 days/week), or SD (high-fat pre-treatment, switched to low-fat chow, no exercise). Outcome measurements were made on weekly saphenous vein blood samples using 3-color flow cytometry. Blood glucose and cholesterol concentration were analyzed weekly. RESULTS: All groups lost significant body weight over 8-weeks (P<0.001). V-EX lost 36.4% and F-EX lost 27.1% from baseline to week 8 (P<0.001). V-EX ran 4.4x times more than F-EX (P<0.001). There were no significant effects for blood cholesterol. CN had 26% higher glucose levels than V-EX (P=0.009). At week 8, the concentration of monocytes expressing TLR2 was 6x higher than week 1 (P=0.002). V-EX was 48.9% higher than CN and 58.9% higher than F-EX (P=0.004). The cell-surface expression of TLR2 at baseline was 54.6% lower than week 6 and 22.9% lower than week 8. No significant differences for the concentration of monocytes expressing TLR4 were found. At baseline, the cell-surface expression of TLR4 was 33.3% lower than week 8 (P<0.001). CONCLUSION: Consumption of a low-fat diet and exercise caused significant weight loss following 12-months of high-fat feeding. Voluntary exercise reversed the increases in glucose. Diet and exercise increased cell-surface expression of TLR2/TLR4, with V-EX changing less overall. Since V-EX ran significantly more than F-EX; more research is needed to determine whether it is the mode or distance that caused the changes." @default.
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• W2038874849 date "2010-05-01" @default.
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• W2038874849 title "The Effects Of Exercise And A Low-fat Diet On Disease Risk And Monocyte Toll-like Receptor Expression In Mice" @default.
• W2038874849 doi "https://doi.org/10.1249/01.mss.0000385795.09273.57" @default.
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