FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038876912> ?p ?o ?g. }

• W2038876912 endingPage "705" @default.
• W2038876912 startingPage "695" @default.
• W2038876912 abstract "Currently, the use of two classification systems for bladder cancer grade is advocated in clinical guidelines because the WHO2004 classification has not been sufficiently validated with biological markers and follow-up. The slides of 325 primary non-muscle invasive bladder cancers from three hospitals were reviewed by one uro-pathologist in two separate sessions for the WHO1973 (G1, G2 and G3) and 2004 (papillary urothelial neoplasm of low malignant potential (LMP), low-grade (LG) and high-grade (HG)) classifications. FGFR3 status was examined with PCR-SNaPshot analysis. Expression of Ki-67, P53 and P27 was analyzed by immuno-histochemistry. Clinical recurrence and progression were determined. We performed validation and cross-validation of the two systems for grade with molecular markers and clinical outcome. Multivariable analyses were done to predict prognosis and pT1 bladder cancer. Grade review resulted in 88 G1, 149 G2 and 88 G3 lesions (WHO1973) and 79 LMP, 101 LG and 145 HG lesions (WHO2004). Molecular validation of both grading systems showed that FGFR3 mutations were associated with lower grades whereas altered expression (Ki-67, P53 and P27) was found in higher grades. Clinical validation showed that the two classification systems were both significant predictors for progression but not for recurrence. Cross-validation of both WHO systems showed a significant stepwise increase in biological (molecular markers) and clinical (progression) potential along the line: G1—LG—G2—HG—G3. The LMP and G1 categories had a similar clinical and molecular profile. On the basis of molecular biology and multivariable clinical data, our results support a four-tiered grading system using the 1973 and 2004 WHO classifications with one low-grade (LMP/LG/G1) category that includes LMP, two intermediate grade (LG/G2 and HG/G2) categories and one high-grade (HG/G3) category." @default.
• W2038876912 created "2016-06-24" @default.
• W2038876912 creator A5012397578 @default.
• W2038876912 creator A5013406375 @default.
• W2038876912 creator A5026058364 @default.
• W2038876912 creator A5038176751 @default.
• W2038876912 creator A5049762337 @default.
• W2038876912 creator A5057092796 @default.
• W2038876912 creator A5057500759 @default.
• W2038876912 creator A5063370423 @default.
• W2038876912 creator A5067932199 @default.
• W2038876912 creator A5077999992 @default.
• W2038876912 creator A5081783286 @default.
• W2038876912 creator A5083000708 @default.
• W2038876912 creator A5086355643 @default.
• W2038876912 creator A5090079374 @default.
• W2038876912 date "2015-05-01" @default.
• W2038876912 modified "2023-10-03" @default.
• W2038876912 title "Molecular and clinical support for a four-tiered grading system for bladder cancer based on the WHO 1973 and 2004 classifications" @default.
• W2038876912 cites W1563019250 @default.
• W2038876912 cites W1606117260 @default.
• W2038876912 cites W1928271534 @default.
• W2038876912 cites W1964185454 @default.
• W2038876912 cites W1991079778 @default.
• W2038876912 cites W2000300696 @default.
• W2038876912 cites W2000722309 @default.
• W2038876912 cites W2000837090 @default.
• W2038876912 cites W2002045993 @default.
• W2038876912 cites W2012966395 @default.
• W2038876912 cites W2020276030 @default.
• W2038876912 cites W2022067739 @default.
• W2038876912 cites W2023543764 @default.
• W2038876912 cites W2028650221 @default.
• W2038876912 cites W2031541885 @default.
• W2038876912 cites W2032005128 @default.
• W2038876912 cites W2057179294 @default.
• W2038876912 cites W2057691584 @default.
• W2038876912 cites W2070878701 @default.
• W2038876912 cites W2085649383 @default.
• W2038876912 cites W2099900006 @default.
• W2038876912 cites W2119444977 @default.
• W2038876912 cites W2132952780 @default.
• W2038876912 cites W2139260705 @default.
• W2038876912 cites W2143033064 @default.
• W2038876912 cites W2151781453 @default.
• W2038876912 cites W2152455106 @default.
• W2038876912 cites W2155829623 @default.
• W2038876912 cites W2161088423 @default.
• W2038876912 cites W2161817637 @default.
• W2038876912 cites W2275614507 @default.
• W2038876912 doi "https://doi.org/10.1038/modpathol.2014.154" @default.
• W2038876912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25431236" @default.
• W2038876912 hasPublicationYear "2015" @default.
• W2038876912 type Work @default.
• W2038876912 sameAs 2038876912 @default.
• W2038876912 citedByCount "34" @default.
• W2038876912 countsByYear W20388769122015 @default.
• W2038876912 countsByYear W20388769122016 @default.
• W2038876912 countsByYear W20388769122017 @default.
• W2038876912 countsByYear W20388769122019 @default.
• W2038876912 countsByYear W20388769122020 @default.
• W2038876912 countsByYear W20388769122021 @default.
• W2038876912 countsByYear W20388769122022 @default.
• W2038876912 countsByYear W20388769122023 @default.
• W2038876912 crossrefType "journal-article" @default.
• W2038876912 hasAuthorship W2038876912A5012397578 @default.
• W2038876912 hasAuthorship W2038876912A5013406375 @default.
• W2038876912 hasAuthorship W2038876912A5026058364 @default.
• W2038876912 hasAuthorship W2038876912A5038176751 @default.
• W2038876912 hasAuthorship W2038876912A5049762337 @default.
• W2038876912 hasAuthorship W2038876912A5057092796 @default.
• W2038876912 hasAuthorship W2038876912A5057500759 @default.
• W2038876912 hasAuthorship W2038876912A5063370423 @default.
• W2038876912 hasAuthorship W2038876912A5067932199 @default.
• W2038876912 hasAuthorship W2038876912A5077999992 @default.
• W2038876912 hasAuthorship W2038876912A5081783286 @default.
• W2038876912 hasAuthorship W2038876912A5083000708 @default.
• W2038876912 hasAuthorship W2038876912A5086355643 @default.
• W2038876912 hasAuthorship W2038876912A5090079374 @default.
• W2038876912 hasBestOaLocation W20388769121 @default.
• W2038876912 hasConcept C121608353 @default.
• W2038876912 hasConcept C126322002 @default.
• W2038876912 hasConcept C142724271 @default.
• W2038876912 hasConcept C143998085 @default.
• W2038876912 hasConcept C18903297 @default.
• W2038876912 hasConcept C2777286243 @default.
• W2038876912 hasConcept C2780352672 @default.
• W2038876912 hasConcept C71924100 @default.
• W2038876912 hasConcept C86803240 @default.
• W2038876912 hasConceptScore W2038876912C121608353 @default.
• W2038876912 hasConceptScore W2038876912C126322002 @default.
• W2038876912 hasConceptScore W2038876912C142724271 @default.
• W2038876912 hasConceptScore W2038876912C143998085 @default.
• W2038876912 hasConceptScore W2038876912C18903297 @default.
• W2038876912 hasConceptScore W2038876912C2777286243 @default.
• W2038876912 hasConceptScore W2038876912C2780352672 @default.
• W2038876912 hasConceptScore W2038876912C71924100 @default.
• W2038876912 hasConceptScore W2038876912C86803240 @default.

• next