Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038888907> ?p ?o ?g. }
- W2038888907 endingPage "235" @default.
- W2038888907 startingPage "227" @default.
- W2038888907 abstract "Purpose of review Preclinical research in epileptology has been very successful in developing antiseizure drugs (ASDs). Several preclinical proof-of-concept studies have also provided evidence for positive treatment effects of some antiepileptogenic drugs to prevent the development of epilepsy. Disappointingly, all human antiepileptogenesis trials to prevent epilepsy after brain insults have failed, because of several reasons. Recent findings None of the currently available ASDs have been shown to prevent epilepsy after stroke, traumatic brain injury, or in brain tumours. Retrospective series and post-hoc analyses of randomized controlled trials of patients undergoing combined radiochemotherapy for malignant glioblastoma found an increased survival of patients with valproate, thus suggesting a possible role against the symptoms related to the comorbidity of epilepsy in these patients. Target-oriented treatments such as rapamycin and everolimus are currently under clinical investigation to prevent epilepsy in patients with tuberous sclerosis. Summary An orchestrated effort among basic and clinical scientists is needed to develop proper antiepileptogenic drugs, powerful biomarkers, and valid clinical trial designs to bring new treatments on the market that can successfully prevent epilepsy." @default.
- W2038888907 created "2016-06-24" @default.
- W2038888907 creator A5030489393 @default.
- W2038888907 creator A5076045134 @default.
- W2038888907 date "2014-04-01" @default.
- W2038888907 modified "2023-10-17" @default.
- W2038888907 title "Antiepileptogenesis in humans" @default.
- W2038888907 cites W1492931325 @default.
- W2038888907 cites W1524734265 @default.
- W2038888907 cites W1563061718 @default.
- W2038888907 cites W1563739868 @default.
- W2038888907 cites W1896206937 @default.
- W2038888907 cites W1898035317 @default.
- W2038888907 cites W1910922994 @default.
- W2038888907 cites W1965953789 @default.
- W2038888907 cites W1970117905 @default.
- W2038888907 cites W1975985332 @default.
- W2038888907 cites W1977830444 @default.
- W2038888907 cites W1988931044 @default.
- W2038888907 cites W1989130417 @default.
- W2038888907 cites W1990638963 @default.
- W2038888907 cites W1991147561 @default.
- W2038888907 cites W1999519693 @default.
- W2038888907 cites W2005549417 @default.
- W2038888907 cites W2006056753 @default.
- W2038888907 cites W2006139919 @default.
- W2038888907 cites W2013865024 @default.
- W2038888907 cites W2015291504 @default.
- W2038888907 cites W2017083014 @default.
- W2038888907 cites W2020372671 @default.
- W2038888907 cites W2022831183 @default.
- W2038888907 cites W2022981588 @default.
- W2038888907 cites W2028680985 @default.
- W2038888907 cites W2030113059 @default.
- W2038888907 cites W2038026687 @default.
- W2038888907 cites W2041524723 @default.
- W2038888907 cites W2061742208 @default.
- W2038888907 cites W2063639039 @default.
- W2038888907 cites W2064923219 @default.
- W2038888907 cites W2066284829 @default.
- W2038888907 cites W2069586118 @default.
- W2038888907 cites W2069683264 @default.
- W2038888907 cites W2072163430 @default.
- W2038888907 cites W2074588573 @default.
- W2038888907 cites W2075368299 @default.
- W2038888907 cites W2078789079 @default.
- W2038888907 cites W2091406481 @default.
- W2038888907 cites W2091956563 @default.
- W2038888907 cites W2098071052 @default.
- W2038888907 cites W2100183499 @default.
- W2038888907 cites W2103571756 @default.
- W2038888907 cites W2111223783 @default.
- W2038888907 cites W2119967224 @default.
- W2038888907 cites W2126274301 @default.
- W2038888907 cites W2129934770 @default.
- W2038888907 cites W2142482104 @default.
- W2038888907 cites W2150439100 @default.
- W2038888907 cites W2150857727 @default.
- W2038888907 cites W2151297008 @default.
- W2038888907 cites W2151485047 @default.
- W2038888907 cites W2154442235 @default.
- W2038888907 cites W2160223635 @default.
- W2038888907 cites W2203865877 @default.
- W2038888907 cites W2316525940 @default.
- W2038888907 cites W2325851205 @default.
- W2038888907 cites W2332522282 @default.
- W2038888907 cites W2409298471 @default.
- W2038888907 cites W2765754703 @default.
- W2038888907 cites W4252414228 @default.
- W2038888907 doi "https://doi.org/10.1097/wco.0000000000000067" @default.
- W2038888907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24556736" @default.
- W2038888907 hasPublicationYear "2014" @default.
- W2038888907 type Work @default.
- W2038888907 sameAs 2038888907 @default.
- W2038888907 citedByCount "53" @default.
- W2038888907 countsByYear W20388889072014 @default.
- W2038888907 countsByYear W20388889072015 @default.
- W2038888907 countsByYear W20388889072016 @default.
- W2038888907 countsByYear W20388889072017 @default.
- W2038888907 countsByYear W20388889072018 @default.
- W2038888907 countsByYear W20388889072019 @default.
- W2038888907 countsByYear W20388889072020 @default.
- W2038888907 countsByYear W20388889072021 @default.
- W2038888907 countsByYear W20388889072022 @default.
- W2038888907 countsByYear W20388889072023 @default.
- W2038888907 crossrefType "journal-article" @default.
- W2038888907 hasAuthorship W2038888907A5030489393 @default.
- W2038888907 hasAuthorship W2038888907A5076045134 @default.
- W2038888907 hasConcept C118552586 @default.
- W2038888907 hasConcept C126322002 @default.
- W2038888907 hasConcept C143998085 @default.
- W2038888907 hasConcept C168563851 @default.
- W2038888907 hasConcept C177713679 @default.
- W2038888907 hasConcept C2777597344 @default.
- W2038888907 hasConcept C2778186239 @default.
- W2038888907 hasConcept C2778980267 @default.
- W2038888907 hasConcept C2781099131 @default.
- W2038888907 hasConcept C535046627 @default.