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- W2038891923 abstract "The effects of aclarubicin on endothelium-dependent and -independent vasorelaxations were investigated in aortic strips from rats. Aclarubicin (5.9-23.6 microM) inhibited endothelium-dependent relaxation and the increment of the cyclic GMP level in aortic strips in response to acetylcholine but not the endothelium-independent relaxation and the increase of cyclic GMP level in response to sodium nitroprusside. Aclarubicin also inhibited endothelium-dependent relaxations in response to ATP and calcium ionophore A23187. These results suggest that aclarubicin can inhibit endothelium-dependent relaxation by acting somewhere distal to receptor stimulation in vascular endothelial cells." @default.
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- W2038891923 date "1991-03-01" @default.
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- W2038891923 title "Inhibitory Effect of Aclarubicin on Endothelium-Dependent Relaxation of Rat Aorta" @default.
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- W2038891923 doi "https://doi.org/10.1111/j.1600-0773.1991.tb01220.x" @default.
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