FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038898103> ?p ?o ?g. }

• W2038898103 endingPage "345" @default.
• W2038898103 startingPage "335" @default.
• W2038898103 abstract "Autotransporters (ATs) are large virulence factors secreted by Gram-negative bacteria. The passenger domain, carrying the virulence functions, is transported across the bacterial outer membrane in a step that is facilitated by a C-terminal β-domain. This domain folds into a β-barrel with a central aqueous pore of ∼ 1 nm inner diameter according to crystal structures. However, these static dimensions are not compatible with the observed secretion of passengers that may contain natural short-spaced disulfide bonds or artificially fused folded elements. Here, we have systematically analyzed the dimensions of the active AT passenger translocator by inserting peptides of different length and structural complexity in the passenger of the AT hemoglobin protease. The peptides were introduced in a short loop protruding from the main structure and flanked by two single cysteines. Our results show that the attained secondary structure may be more critical for secretion than the length of peptide inserted. Furthermore, the data suggest that, during passenger translocation, at least four extended polypeptides or an extended polypeptide and an α-helix are accommodated in the translocator, indicating that the diameter of the active translocation pore is up to 1.7 nm. If the β-domain functions as the translocator, it must be forced into an expanded conformation during passenger translocation." @default.
• W2038898103 created "2016-06-24" @default.
• W2038898103 creator A5007699425 @default.
• W2038898103 creator A5009549165 @default.
• W2038898103 creator A5053483961 @default.
• W2038898103 creator A5090879577 @default.
• W2038898103 date "2012-02-01" @default.
• W2038898103 modified "2023-09-28" @default.
• W2038898103 title "Estimating the Size of the Active Translocation Pore of an Autotransporter" @default.
• W2038898103 cites W1503488066 @default.
• W2038898103 cites W1518421544 @default.
• W2038898103 cites W1662846517 @default.
• W2038898103 cites W1901866440 @default.
• W2038898103 cites W1958001693 @default.
• W2038898103 cites W1971856033 @default.
• W2038898103 cites W1980034554 @default.
• W2038898103 cites W1991736406 @default.
• W2038898103 cites W2015976014 @default.
• W2038898103 cites W2029180535 @default.
• W2038898103 cites W2029979610 @default.
• W2038898103 cites W2036205039 @default.
• W2038898103 cites W2044548799 @default.
• W2038898103 cites W2046089352 @default.
• W2038898103 cites W2053754839 @default.
• W2038898103 cites W2085019401 @default.
• W2038898103 cites W2099548197 @default.
• W2038898103 cites W2104128981 @default.
• W2038898103 cites W2105026925 @default.
• W2038898103 cites W2112393035 @default.
• W2038898103 cites W2113442468 @default.
• W2038898103 cites W2114623459 @default.
• W2038898103 cites W2114872465 @default.
• W2038898103 cites W2116203390 @default.
• W2038898103 cites W2118978296 @default.
• W2038898103 cites W2127641431 @default.
• W2038898103 cites W2140816237 @default.
• W2038898103 cites W2148828623 @default.
• W2038898103 cites W2149461468 @default.
• W2038898103 cites W2149638691 @default.
• W2038898103 cites W2150189250 @default.
• W2038898103 cites W2167626257 @default.
• W2038898103 cites W2170005333 @default.
• W2038898103 cites W2171651950 @default.
• W2038898103 cites W36310178 @default.
• W2038898103 cites W4237713788 @default.
• W2038898103 doi "https://doi.org/10.1016/j.jmb.2011.12.047" @default.
• W2038898103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22227392" @default.
• W2038898103 hasPublicationYear "2012" @default.
• W2038898103 type Work @default.
• W2038898103 sameAs 2038898103 @default.
• W2038898103 citedByCount "29" @default.
• W2038898103 countsByYear W20388981032012 @default.
• W2038898103 countsByYear W20388981032013 @default.
• W2038898103 countsByYear W20388981032014 @default.
• W2038898103 countsByYear W20388981032015 @default.
• W2038898103 countsByYear W20388981032016 @default.
• W2038898103 countsByYear W20388981032017 @default.
• W2038898103 countsByYear W20388981032018 @default.
• W2038898103 countsByYear W20388981032019 @default.
• W2038898103 countsByYear W20388981032020 @default.
• W2038898103 countsByYear W20388981032021 @default.
• W2038898103 crossrefType "journal-article" @default.
• W2038898103 hasAuthorship W2038898103A5007699425 @default.
• W2038898103 hasAuthorship W2038898103A5009549165 @default.
• W2038898103 hasAuthorship W2038898103A5053483961 @default.
• W2038898103 hasAuthorship W2038898103A5090879577 @default.
• W2038898103 hasConcept C104317684 @default.
• W2038898103 hasConcept C12554922 @default.
• W2038898103 hasConcept C138626823 @default.
• W2038898103 hasConcept C146587185 @default.
• W2038898103 hasConcept C185592680 @default.
• W2038898103 hasConcept C18903297 @default.
• W2038898103 hasConcept C203014093 @default.
• W2038898103 hasConcept C2776791281 @default.
• W2038898103 hasConcept C2776914184 @default.
• W2038898103 hasConcept C2778530040 @default.
• W2038898103 hasConcept C2779965526 @default.
• W2038898103 hasConcept C49039625 @default.
• W2038898103 hasConcept C547475151 @default.
• W2038898103 hasConcept C55493867 @default.
• W2038898103 hasConcept C8010536 @default.
• W2038898103 hasConcept C86803240 @default.
• W2038898103 hasConcept C87753298 @default.
• W2038898103 hasConceptScore W2038898103C104317684 @default.
• W2038898103 hasConceptScore W2038898103C12554922 @default.
• W2038898103 hasConceptScore W2038898103C138626823 @default.
• W2038898103 hasConceptScore W2038898103C146587185 @default.
• W2038898103 hasConceptScore W2038898103C185592680 @default.
• W2038898103 hasConceptScore W2038898103C18903297 @default.
• W2038898103 hasConceptScore W2038898103C203014093 @default.
• W2038898103 hasConceptScore W2038898103C2776791281 @default.
• W2038898103 hasConceptScore W2038898103C2776914184 @default.
• W2038898103 hasConceptScore W2038898103C2778530040 @default.
• W2038898103 hasConceptScore W2038898103C2779965526 @default.
• W2038898103 hasConceptScore W2038898103C49039625 @default.
• W2038898103 hasConceptScore W2038898103C547475151 @default.
• W2038898103 hasConceptScore W2038898103C55493867 @default.
• W2038898103 hasConceptScore W2038898103C8010536 @default.

• next