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• W2038907514 abstract "We designed, fabricated, and tested a microfluidic device for separation of plasma from whole human blood by size exclusion in a cross-flow. The device is made of a single mold of a silicone elastomer poly(dimethylsiloxane) (PDMS) sealed with a cover glass and is essentially disposable. When loaded with blood diluted to 20% hematocrit and driven with pulsatile pressure to prevent clogging of the channels with blood cells, the device can operate for at least 1 h, extracting approximately 8% of blood volume as plasma at an average rate of 0.65 microL/min. The flow in the device causes very little hemolysis; the extracted plasma meets the standards for common assays and is delivered to the device outlet approximately 30 s after injection of blood to the inlet. Integration of the cross-flow microchannel array with on-chip assay elements would create a microanalysis system for point-of-care diagnostics, reducing costs, turn-around times, and volumes of blood sample and reagents required for the assays." @default.
• W2038907514 created "2016-06-24" @default.
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• W2038907514 date "2006-04-26" @default.
• W2038907514 modified "2023-10-14" @default.
• W2038907514 title "Separation of Plasma from Whole Human Blood in a Continuous Cross-Flow in a Molded Microfluidic Device" @default.
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• W2038907514 doi "https://doi.org/10.1021/ac060042r" @default.
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