FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038934678> ?p ?o ?g. }

• W2038934678 endingPage "620" @default.
• W2038934678 startingPage "609" @default.
• W2038934678 abstract "In Brief Objective: Lasofoxifene, a new selective estrogen-receptor modulator (SERM), shows efficacy in vaginal and vulvar atrophy in postmenopausal women. Here, we sought to explore the possible mechanisms of action for this effect in comparison with other SERMs using an immature ovariectomized rat model. Design: SERMs (lasofoxifene, raloxifene, and tamoxifen) and 17α-ethinyl estradiol were administered orally to immature ovariectomized rats daily for 1 or 4 days. Vaginal and uterine tissues were weighed and processed for histomorphometric measurements, vaginal mucopolysaccharide staining, and immunohistochemistry of 5-bromo-2′-deoxyuridine and steroid receptors. Receptor quantification was determined by a novel ultrasensitive enzyme-linked immunosorbent assay method. Results: Lasofoxifene and raloxifene showed a minimal increase in vaginal and uterine weight, epithelial cell proliferation, and epithelial thickness in comparison with estradiol and tamoxifen. Lasofoxifene significantly enhanced vaginal mucus formation in a dose-dependent manner. Vaginal progesterone receptor protein was increased fivefold by estradiol and all three SERMs tested. 17α-Ethinyl estradiol caused a significant decrease in estrogen receptor α, but no change with other treatments. Only lasofoxifene significantly increased vaginal estrogen receptor β and androgen receptor protein levels. Conclusions: These results demonstrated that lasofoxifene stimulated vaginal mucus formation without causing cell proliferation in the rat reproductive tract. These effects may be due to the increased vaginal estrogen receptor β and androgen receptor levels. This cellular and molecular profile of lasofoxifene in the vagina may account for its efficacy in the treatment of vaginal and vulvar atrophy in postmenopausal women. Lasofoxifene stimulated vaginal mucification without causing vaginal or uterine cell proliferation. These unique effects of lasofoxifene may be attributed to an increase in estrogen receptor β and androgen receptor." @default.
• W2038934678 created "2016-06-24" @default.
• W2038934678 creator A5001591660 @default.
• W2038934678 creator A5041441402 @default.
• W2038934678 creator A5047941278 @default.
• W2038934678 creator A5050621294 @default.
• W2038934678 creator A5072259679 @default.
• W2038934678 date "2006-07-01" @default.
• W2038934678 modified "2023-10-18" @default.
• W2038934678 title "Lasofoxifene enhances vaginal mucus formation without causing hypertrophy and increases estrogen receptor β and androgen receptor in rats" @default.
• W2038934678 cites W1565193167 @default.
• W2038934678 cites W1593442063 @default.
• W2038934678 cites W1596203177 @default.
• W2038934678 cites W1848156198 @default.
• W2038934678 cites W1979898922 @default.
• W2038934678 cites W1997883187 @default.
• W2038934678 cites W2011858913 @default.
• W2038934678 cites W2048863570 @default.
• W2038934678 cites W2051515780 @default.
• W2038934678 cites W2051976745 @default.
• W2038934678 cites W2055915536 @default.
• W2038934678 cites W2060441344 @default.
• W2038934678 cites W2060756680 @default.
• W2038934678 cites W2065022554 @default.
• W2038934678 cites W2069249560 @default.
• W2038934678 cites W2072499093 @default.
• W2038934678 cites W2074893064 @default.
• W2038934678 cites W2074919272 @default.
• W2038934678 cites W2075237337 @default.
• W2038934678 cites W2079450135 @default.
• W2038934678 cites W2079550192 @default.
• W2038934678 cites W2086657395 @default.
• W2038934678 cites W2095131494 @default.
• W2038934678 cites W2095636976 @default.
• W2038934678 cites W2100323988 @default.
• W2038934678 cites W2102477226 @default.
• W2038934678 cites W2103062478 @default.
• W2038934678 cites W2112577860 @default.
• W2038934678 cites W2113259481 @default.
• W2038934678 cites W2153259010 @default.
• W2038934678 cites W2166537089 @default.
• W2038934678 cites W2170976149 @default.
• W2038934678 doi "https://doi.org/10.1097/01.gme.0000227337.73738.c9" @default.
• W2038934678 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16837883" @default.
• W2038934678 hasPublicationYear "2006" @default.
• W2038934678 type Work @default.
• W2038934678 sameAs 2038934678 @default.
• W2038934678 citedByCount "29" @default.
• W2038934678 countsByYear W20389346782013 @default.
• W2038934678 countsByYear W20389346782014 @default.
• W2038934678 countsByYear W20389346782015 @default.
• W2038934678 countsByYear W20389346782016 @default.
• W2038934678 countsByYear W20389346782019 @default.
• W2038934678 crossrefType "journal-article" @default.
• W2038934678 hasAuthorship W2038934678A5001591660 @default.
• W2038934678 hasAuthorship W2038934678A5041441402 @default.
• W2038934678 hasAuthorship W2038934678A5047941278 @default.
• W2038934678 hasAuthorship W2038934678A5050621294 @default.
• W2038934678 hasAuthorship W2038934678A5072259679 @default.
• W2038934678 hasConcept C121608353 @default.
• W2038934678 hasConcept C126322002 @default.
• W2038934678 hasConcept C134018914 @default.
• W2038934678 hasConcept C2776917545 @default.
• W2038934678 hasConcept C2777164284 @default.
• W2038934678 hasConcept C2777176818 @default.
• W2038934678 hasConcept C2777944059 @default.
• W2038934678 hasConcept C2779889926 @default.
• W2038934678 hasConcept C2780192828 @default.
• W2038934678 hasConcept C530470458 @default.
• W2038934678 hasConcept C61367390 @default.
• W2038934678 hasConcept C71924100 @default.
• W2038934678 hasConcept C84606932 @default.
• W2038934678 hasConcept C98717036 @default.
• W2038934678 hasConceptScore W2038934678C121608353 @default.
• W2038934678 hasConceptScore W2038934678C126322002 @default.
• W2038934678 hasConceptScore W2038934678C134018914 @default.
• W2038934678 hasConceptScore W2038934678C2776917545 @default.
• W2038934678 hasConceptScore W2038934678C2777164284 @default.
• W2038934678 hasConceptScore W2038934678C2777176818 @default.
• W2038934678 hasConceptScore W2038934678C2777944059 @default.
• W2038934678 hasConceptScore W2038934678C2779889926 @default.
• W2038934678 hasConceptScore W2038934678C2780192828 @default.
• W2038934678 hasConceptScore W2038934678C530470458 @default.
• W2038934678 hasConceptScore W2038934678C61367390 @default.
• W2038934678 hasConceptScore W2038934678C71924100 @default.
• W2038934678 hasConceptScore W2038934678C84606932 @default.
• W2038934678 hasConceptScore W2038934678C98717036 @default.
• W2038934678 hasIssue "4" @default.
• W2038934678 hasLocation W20389346781 @default.
• W2038934678 hasLocation W20389346782 @default.
• W2038934678 hasOpenAccess W2038934678 @default.
• W2038934678 hasPrimaryLocation W20389346781 @default.
• W2038934678 hasRelatedWork W1986507544 @default.
• W2038934678 hasRelatedWork W2006360026 @default.
• W2038934678 hasRelatedWork W2047944159 @default.
• W2038934678 hasRelatedWork W2072183288 @default.
• W2038934678 hasRelatedWork W2090313931 @default.
• W2038934678 hasRelatedWork W2093476509 @default.

• next