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- W2038935575 abstract "Bleomycin which nicks DNA, contains 0.2 mole % Fe. It enhances the rate of nicking of PM2-CCC-DNA produced by low concentrations of Fe 2+ salts. The reaction under both conditions is dependent on oxygen and is strongly inhibited by (i) superoxide dismutase, (ii) catalase and more efficiently by the two enzymes together, and (iii) free radical scavengers, e.g. isopropyl alcohol, indicating the intermediacy in the cleavage of 0 2 − ·, H 2 O 2 and OH· respectively. 2-Mercaptoethanol, dithiothreitol, ascorbic acid and xanthine/xanthine oxidase, hitherto commonly used with bleomycin studies, separately cleave DNA by a similar mechanism. CuSO 4 (but not Co, Mn, Zn or Mg salts) with NADPH nicks DNA by the superoxide pathway but is inhibited by bleomycin which sequesters the Cu 2+ and prevents its reduction." @default.
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- W2038935575 date "1977-08-01" @default.
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- W2038935575 title "The mechanism of the bleomycin-induced cleavage of DNA" @default.
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- W2038935575 doi "https://doi.org/10.1016/s0006-291x(77)80099-5" @default.
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