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- W2038951113 abstract "Abstract The stimulatory effect of drugs on the biosynthesis of l -ascorbic acid, d -glucaric acid and l -xylulose1−4, can be explained by an increased formation of the common intermediate d -glucuronic acid or its lactone from UDPG. 5This effect results in an increased urinary excretion of the mentioned products by treated mammals. In studies of this phenomenon we observed that male rats respond more to drug treatment than female rats. Barbital, chlorophenothane, nikethamide and chloretone were studied. These drugs displayed a strong stimulatory effect on l -ascorbic acid excretion. Urinary excretion of d -glucaric acid was studied only in the case of barbital. Adult rats were treated orally on three successive days, with 50, 100, and 150 mg/kg sodium barbital respectively. Before treatment no significant difference was observed between males and females in the l -ascorbic acid and d -glucaric acid excretion. On the days of drug treatment there was an increase in l -ascorbic acid excretion, which was significantly higher in males than in females. d -glucaric acid excretion, measured only on the third day of treatment was found to be increased. Again the increase was higher in males than in females (Fig. 1). Chlorophenothane, nikethamide and chloretone gave as far as the urinary excretion of l -ascorbic acid is concerned, the same type of sex difference. The data are summarized in Table 1." @default.
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- W2038951113 date "1968-02-01" @default.
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- W2038951113 title "Sex difference in the stimulatory effect of drugs on carbohydrate metabolism through the glucuronic acid pathways studied on the rat" @default.
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- W2038951113 doi "https://doi.org/10.1016/0006-2952(68)90337-7" @default.
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