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- W2038962708 abstract "Alzheimer's disease (AD) is a progressive neurodegenerative disease associated with senileamyloid-b (A b) plaques, neuronal death, and cognitive decline. Neurogenesis in the adult hippocampus, which is notably affected by progressive neurodegeneration and Aß pathology, is implicated in learning and memory regulation. Human postmortem brains of AD patients and APP/Ps1 double transgenic mice show increased neurodegeneration. Leptin, an adipose-derived hormone, promotes neurogenesis in the adult hippocampus, but the way in which this process occurs in the AD brain is still unknown. Thus, we sought to determine if leptin stimulated the proliferation of neuronal precursors in APP/Ps1 mice. We estimated the number proliferating hippocampal cells after intracerebroventricular administration of a lent viral vector encoding leptin. After 3 months of treatment with leptin we observed an increase in the number of BrdU-positive cells in the sub granular zone of the dentategyrus, as shown by morphometric analysis. This increase resulted mainly from an increased proliferation of neuronal precursors. Additionally, leptin led to an attenuation of A b-induced neurodegeneration, as revealed by Fluoro-Jadestaining. Our results suggest that in APP/Ps1 mice, leptin exerts changes resembling acute neurotrophic and neuroprotective effects. These effects could serve as the basis for the design of future treatment strategies in AD." @default.
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- W2038962708 date "2011-07-01" @default.
- W2038962708 modified "2023-09-27" @default.
- W2038962708 title "P3-424: Leptin induces proliferation of neuronal progenitors and neuroprotection in a mouse model of Alzheimer's disease" @default.
- W2038962708 doi "https://doi.org/10.1016/j.jalz.2011.05.1868" @default.
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