FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038962904> ?p ?o ?g. }

• W2038962904 endingPage "1146" @default.
• W2038962904 startingPage "1136" @default.
• W2038962904 abstract "There is uncertainty regarding the association of cognitive decline in Alzheimer disease (AD) with classic histopathologic features- neurofibrillary tangles (NFTs) and neuritic amyloid plaques (NPs). This uncertainty fuels doubts about the diagnostic importance of NFTs and NPs and leads to confusion regarding hypotheses of AD pathogenesis. Three hundred ninety subjects who underwent longitudinal premortem clinical workup and postmortem quantitative neuropathologic assessment served as the group to address this issue. Subjects with concomitant brain disease(s) were analyzed independently to more accurately assess the contribution of distinct pathologies to cognitive decline. More than 60% of patients of all age groups had important non-AD brain pathologies. However, subjects without superimposed brain diseases showed strong correlations between AD-type pathology counts (NFTs > NPs) and premortem Mini-Mental State Examination scores. The observed correlation was stronger in isocortex than in allocortex and was maintained across age groups including patients older than 90 years. A theoretical model is proposed in which our results are interpreted to support the amyloid cascade hypothesis of AD pathogenesis. Our data show that there are many important contributory causes to cognitive decline in older persons. However, NFTs and NPs should not be dismissed as irrelevant in AD based on clinicopathologic correlation." @default.
• W2038962904 created "2016-06-24" @default.
• W2038962904 creator A5007368132 @default.
• W2038962904 creator A5009032548 @default.
• W2038962904 creator A5014819568 @default.
• W2038962904 creator A5017179392 @default.
• W2038962904 creator A5018433704 @default.
• W2038962904 creator A5021996221 @default.
• W2038962904 creator A5048341091 @default.
• W2038962904 creator A5065589335 @default.
• W2038962904 date "2007-12-01" @default.
• W2038962904 modified "2023-10-02" @default.
• W2038962904 title "Clinicopathologic Correlations in a Large Alzheimer Disease Center Autopsy Cohort" @default.
• W2038962904 cites W1483229283 @default.
• W2038962904 cites W1602781425 @default.
• W2038962904 cites W1746907828 @default.
• W2038962904 cites W1972147129 @default.
• W2038962904 cites W1972186270 @default.
• W2038962904 cites W1972340735 @default.
• W2038962904 cites W1983282949 @default.
• W2038962904 cites W1984283611 @default.
• W2038962904 cites W1984514250 @default.
• W2038962904 cites W1997013066 @default.
• W2038962904 cites W1997025239 @default.
• W2038962904 cites W1997466909 @default.
• W2038962904 cites W2005503435 @default.
• W2038962904 cites W2006247983 @default.
• W2038962904 cites W2008571443 @default.
• W2038962904 cites W2016018983 @default.
• W2038962904 cites W2016436495 @default.
• W2038962904 cites W2019428673 @default.
• W2038962904 cites W2019503269 @default.
• W2038962904 cites W2022927656 @default.
• W2038962904 cites W2023649381 @default.
• W2038962904 cites W2026100040 @default.
• W2038962904 cites W2030567293 @default.
• W2038962904 cites W2033870077 @default.
• W2038962904 cites W2033917523 @default.
• W2038962904 cites W2036801925 @default.
• W2038962904 cites W2039303134 @default.
• W2038962904 cites W2039802914 @default.
• W2038962904 cites W2040556265 @default.
• W2038962904 cites W2040638009 @default.
• W2038962904 cites W2042065186 @default.
• W2038962904 cites W2046031134 @default.
• W2038962904 cites W2049904796 @default.
• W2038962904 cites W2050177082 @default.
• W2038962904 cites W2050784521 @default.
• W2038962904 cites W2052638161 @default.
• W2038962904 cites W2053116497 @default.
• W2038962904 cites W2055077265 @default.
• W2038962904 cites W2057068434 @default.
• W2038962904 cites W2057144507 @default.
• W2038962904 cites W2066792703 @default.
• W2038962904 cites W2070054259 @default.
• W2038962904 cites W2071148852 @default.
• W2038962904 cites W2072753569 @default.
• W2038962904 cites W2074071789 @default.
• W2038962904 cites W2075412992 @default.
• W2038962904 cites W2075481535 @default.
• W2038962904 cites W2081126811 @default.
• W2038962904 cites W2084617446 @default.
• W2038962904 cites W2084957666 @default.
• W2038962904 cites W2085182512 @default.
• W2038962904 cites W2089716421 @default.
• W2038962904 cites W2091173932 @default.
• W2038962904 cites W2095422335 @default.
• W2038962904 cites W2096410114 @default.
• W2038962904 cites W2097041318 @default.
• W2038962904 cites W2103473142 @default.
• W2038962904 cites W2104855213 @default.
• W2038962904 cites W2125332642 @default.
• W2038962904 cites W2125436534 @default.
• W2038962904 cites W2130110606 @default.
• W2038962904 cites W2132387058 @default.
• W2038962904 cites W2135483015 @default.
• W2038962904 cites W2135771073 @default.
• W2038962904 cites W2136389487 @default.
• W2038962904 cites W2137794576 @default.
• W2038962904 cites W2140542463 @default.
• W2038962904 cites W2145909463 @default.
• W2038962904 cites W2149898458 @default.
• W2038962904 cites W2158624818 @default.
• W2038962904 cites W2159529587 @default.
• W2038962904 cites W2163603138 @default.
• W2038962904 cites W2167232541 @default.
• W2038962904 cites W2331404224 @default.
• W2038962904 cites W2334899545 @default.
• W2038962904 cites W4296588155 @default.
• W2038962904 doi "https://doi.org/10.1097/nen.0b013e31815c5efb" @default.
• W2038962904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3034246" @default.
• W2038962904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18090922" @default.
• W2038962904 hasPublicationYear "2007" @default.
• W2038962904 type Work @default.
• W2038962904 sameAs 2038962904 @default.
• W2038962904 citedByCount "248" @default.
• W2038962904 countsByYear W20389629042012 @default.
• W2038962904 countsByYear W20389629042013 @default.

• next