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• W2038963410 abstract "British Journal of HaematologyVolume 9, Issue 3 p. 319-327 Observations on the Metabolism of Folic Acid in Pernicious Anaemia A. H. Waters, A. H. Waters Department of Haematology, Postgraduate Medical School of London ‡ University of Queensland Travelling Scholar in Medicine.Search for more papers by this authorD. L. Mollin, D. L. Mollin Department of Haematology, Postgraduate Medical School of London ‡ In receipt of a grant from the Medical Research Council.Search for more papers by this author A. H. Waters, A. H. Waters Department of Haematology, Postgraduate Medical School of London ‡ University of Queensland Travelling Scholar in Medicine.Search for more papers by this authorD. L. Mollin, D. L. Mollin Department of Haematology, Postgraduate Medical School of London ‡ In receipt of a grant from the Medical Research Council.Search for more papers by this author First published: July 1963 https://doi.org/10.1111/j.1365-2141.1963.tb06556.xCitations: 90 Postal address: Ducane Road, London, W.12. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES Baker, H., Herbert, V., Frank, O., Pasher, I., Hutner, S. H., Wasserman, L. R. and Sobotka, H. (1959). ‘A microbiologic method for detecting folic acid deficiency in man. Clin. Chem., 5, 275. Chanarin, I., Bennett, M. C. and Berry, V. (1962). ‘Urinary excretion of histidine derivatives in megaloblastic anaemia and other conditions and a comparison with folic acid clearance test. J. chin. Path., 15, 269. Chanarin, I., Mollin, D. L. and Anderson, B. B. (1958). ‘The clearance from the plasma of folic acid injected intravenously in normal subjects and patients with megaloblastic anaemia. Brit. J. Haemat., 4, 435. Chosy. J. J., Clatanoff, D. V. and Schilling, R. F. (1962). ‘Responses to small doses of fclic acid in pernicious anemia. Amer. J. chin. Nutr., 104, 349. Cox, E. V., Meynell, M. J., Cooke, W. T. and Gaddie, R. (1958). ‘Folic acid and cyanocobalamin in pernicious anaemia. Chin. Sci., 17, 693. Dacie, J. V. (1956). Practical Haematology, 2nd edn. Churchill, London . Donaldson, K. O. and Keresztesy, J. C. (1959). ‘Naturally occurring forms of folic acid. I. “Prefolic A”: preparation of concentrate and enzymatic conversion to citrovorum factor. J. biol. Chem., 234, 3255. Donaldson, K. O. and Keresztesy, J. C. (1961). ‘Further evidence on the nature of prefolic A. Biochem. biophys. Res. Comm., 5, 289. Frost, D. V., Lapidus, M., Plaut, K. A., Scherfling, E. and Fricke, H. H. (1952). ‘Differential stability of various analogs of cobalamin to vitamin C. Science, 116, 119. Gibson, F. and Woods, D. D. (1960). ‘The synthesis of methionine by suspensions of Escherichia coli. Biochem. J., 74, 160. Girdwood, R. H. (1952). ‘The occurrence of growth factors for Lactobacillus leiclmanii, Streptococcus faecalis and Leuconostoc citrovorum in the tissues of pernicious anaemia patients and controls. Biochem. J., 52, 58. Girdwood, R. H. (1953). ‘A folic acid excretion test in the investigation of intestinal malabsorption. Lancet, ii, 53. Guest, J. R., Helleiner, C. W., Cross, M. J. and Woods, D. D. (1960). ‘Cobalamin and the synthesis of methionine by ultrasonic extracts of Escherichia coli. Biochem. J., 76, 396. Hansen, H. A. and Weinfeld, A. (1962). ‘Metabolic effects and diagnostic value of small doses of folic acid and B12 in megaloblastic anemias. Acta med. scand., 172, 427. Hatch, F. T., Larrabee, A. R., Cathou, R. E. and Buchanan, J. M. (1961). ‘Enzymatic synthesis of the methyl group of methionine. I. Identification of the enzymes and co-factors involved in the system isolated from Escherichia coli. J. biol. Chem., 236, 1095. Hawkins, C. F. (1955). ‘Value of serum iron levels in assessing effect of haematinics in the macrocytic anaemias. Brit. med. J., i, 383. Herbert, V. (1961). ‘The assay and nature of folic acid activity in human serum. J. chin. Invest., 40, 81. Herbert, V., Baker, H., Frank, O., Pasher, I, Sobotka, H. and Wasserman, L. R. (1960). ‘The measurement of folic acid activity in serum: a diagnostic aid in the differentiation of the megaloblastic anemias. Blood, 15, 228. Herbert, V., Larrabee, A. R. and Buchanan, J. M. (1962). ‘Studies on the identification of a folate compound of human serum. J. chin. Invest., 41, 1134. Herbert, V. and Zalusky, R. (1961). ‘Pteroylglutamic acid (PGA) clearance after intravenous injection: studies using two microbiologic assay organisms. Clin. Res., 9, 161. Hutner, S. H., Bach, M. K. and Ross, G. I. M. (1956). ‘A sugar-containing basal medium for vitamin B12-assay with Euglena; application to body fluids. J. Protozool., 3, 101. Jaenicke, L. (1961). ‘Ein biologisch aktives Methylfolat. Hoppe-Seylers Z. physiol. Chem., 326, 168. Kisliuk, R. L. and Woods, D. D. (1960). ‘Interrelationships between folic acid and cobalamin in the synthesis of methionine by extracts of Escherichia coli. Biochem. J., 75, 467. Knowles, J. P. and Prankerd, T. A. J. (1962). ‘Abnormal folic acid metabolism in vitamin B12 deficiency. Clin. Sci., 22, 233. Kohn, J., Mollin, D. L. and Rosenbach, L. M. (1961). ‘Conventional voltage electrophoresis for formiminoglutamic-acid determination in folic acid deficiency. J. chin. Path., 14, 345. Larrabee, A. R. and Buchanan, J. M. (1961). ‘A new intermediate of methionine biosynthesis. Fed. Proc., 20, 9. Marshall, R. A. and Jandl, J. H. (1960). ‘Responses to “physiologic” doses of folic acid in the megaloblastic anemias. Arch. intern. Med., 105, 352. Mollin, D. L. (1959). ‘ The megaloblastic anaemias. Lectures on the Scientific Basis of Medicine (19571958), Vol. 7, p. 94. Athlone Press, London . Mollin, D. L. (1960). ‘The megaloblastic anemias. Annu. Rev. Med., ii, 333. Mollin, D. L., Waters, A. H. and Harriss, E. (1962). ‘ Clinical aspects of the metabolic interrelationships between folic acid and vitamin B12. Vitamin B12 und Intrinsic Factor. 2 Europäisches Symposion, Hamburg, 1961, p. 737. Enke, Stuttgart . Moore, C. V. and Doan, C. A. (1937). ‘Correlation of serum iron, bone marrow and blood cell changes following specific therapy in the macrocytic anemias. Arch. Path., 23, 738. Mueller, J. F. and Will, J. J. (1955). ‘Interrelationship of folic acid, vitamin B12 and ascorbic acid in patients with megaloblastic anemia. Amer. J. clin. Nutr., 3, 30. Nelson, R. S. and Doctor, V. M. (1958). ‘The vitamin B12 content of human liver as determined by bio-assay of needle biopsy material. Ann. intern. Med., 49, 1361. Rabnrowitz, J. C. (1960). ‘ Folic acid. The Enzymes, Vol. 2, p. 185. Academic Press, London . Rhchard, P. (1959). ‘The enzymatic synthesis of pyrimidines. Advant. Enzymol., 21, 263. Reisner, E. H., Junr (1958). ‘The nature and significance of megaloblastic blood formation. Blood, 13, 313. Ross, G. I. M. and Mollin, D. L. (1957). ‘ Vitamin B12 in tissues in pernicious anaemia and other conditions. Vitamin B12 und Intrinsic Factor. I Europäiches Symposion, Hamburg, 1956, p. 437. Enke, Stuttgart . Sakami, W. and Ukstins, I. (1961). ‘Enzymatic methylation of homocysteine by a synthetic tetrahydrofolate derivative. J. biol. Chem., 236, PC 50. Spray, G. H., Fourman, P. and Witts, L. J. (1951). ‘The excretion of small doses of folic acid. Brit. med. J., ii, 202. Takeyama, S., Hatch, F. T. and Buchanan, J. M. (1961). ‘Enzymatic synthesis of the methyl group of methionine. II. Involvement of vitamin B12. J. biol. Chem., 236, 1102. Vilter, R. W., Horrigan, D., Mueller, J. F., Jarrold, T., Vilter, C. F., Hawkins, V. and Seaman, A. (1950). ‘Studies on the relationships of vitamin B12, folic acid, thymine, uracil and methyl group donors in persons with pernicious anemia and related megaloblastic aneruias. Blood, 5, 695. Waters, A. H. and Mollin, D. L. (1961). ‘Studies on the folic acid activity of human serum. J. clin. Path., 14, 335. Waters, A. H. and Mollin, D. L. (1962). ‘ Serum folic acid activity in normal subjects and patients with megaloblastic anaemia. Proc. 8th Congr., European Soc. Haemat., Vienna, 1961, Paper No. 332. Karger, Basel . Citing Literature Volume9, Issue3July 1963Pages 319-327 ReferencesRelatedInformation" @default.
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