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• W2038963428 abstract "Xyloside supplementation of long-term bone marrow cultures (LTBMCs) has been reported to result in greatly enhanced proliferation of hematopoietic stem cells. This was presumed to be the result of xyloside-mediated perturbation of proteoglycan synthesis by marrow-derived stromal cells. To investigate this phenomenon, we first studied the effects of xyloside supplementation on proteoglycan synthesis by D2XRadll bone marrow stromal cells, which support hematopoietic stem cell proliferation in vitro. D2XRadll cells were precursor labelled with 35S-sulfate, and proteoglycans separated by ion exchange chromatography, isopyknic CsCI gradient centrifugation, and gel filtration HPLC. Xylo-side-supplemented cultures showed an approximately fourfold increase in total 35S incorporation, mainly as free chondroitin-dermatan sulfate (CS/DS) gly-cosaminoglycan chains in the culture media. Both xyloside supplemented and nonsupplemented cultures synthesized DS1, DS2, and DS3 CS/DS proteoglycans as previously described. In contrast to previous reports, xyloside was found to inhibit hematopoietic cell growth in LTBMC. Inhibitory effects were observed both in cocultures of lL-3-dependent hematopoietic cell lines with supportive stromal cell lines and in primary murine LTBMCs. Xyloside was found to have a marked inhibitory effect on the growth of murine hematopoietic stem cells and IL-3-dependent hematopoietic cell lines in clonal assay systems and in suspension cultures. In contrast, dialyzed concentrated conditioned media from LTBMCs had no such inhibitory effects. These findings suggest that xyloside-mediated inhibition of hematopoietic cell growth in LTBMC resulted from a direct effect of xyloside on proteoglycan synthesis by hematopoietic cells." @default.
• W2038963428 created "2016-06-24" @default.
• W2038963428 creator A5000056684 @default.
• W2038963428 creator A5063213274 @default.
• W2038963428 date "1991-07-01" @default.
• W2038963428 modified "2023-09-25" @default.
• W2038963428 title "Xyloside effects on in vitro hematopoiesis: Functional and biochemical studies" @default.
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• W2038963428 doi "https://doi.org/10.1002/jcp.1041480114" @default.
• W2038963428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1860891" @default.
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