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- W2038963510 abstract "Using a polyclonal antibody monospecific to the c-erbB-2 oncogene product, an immunohistochemical study on the expression of c-erbB-2 protein was performed in formalin-fixed, paraffin-embedded tissue sections from 176 primary breast carcinomas in which amplification of the c-erbB-2 gene had been detected in 28 cases. Expression of the c-erbB-2 protein was detected in 44 cases (25%), being strongly positive in 27 (15%) and weakly positive in 17 (10%). All cases with amplification of c-erbB-2 showed positive staining of its protein. There were only four cases in which c-erbB-2 was strongly expressed without amplification of the gene. In the group showing strongly positive staining, both overall and disease-free survival were significantly poorer than in the remainder of the cases. Using Cox's regression model analysis, overexpression of c-erbB-2 protein was demonstrated to be an effective prognostic factor independent of nodal status or tumor size." @default.
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- W2038963510 date "1990-04-01" @default.
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- W2038963510 title "Immunohistochemical Study on Overexpression of c-<i>erb</i>B-2 Protein in Human Breast Cancer: Its Correlation with Gene Amplification and Long-term Survival of Patients" @default.
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- W2038963510 doi "https://doi.org/10.1111/j.1349-7006.1990.tb02571.x" @default.
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