Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038963573> ?p ?o ?g. }
- W2038963573 endingPage "276" @default.
- W2038963573 startingPage "265" @default.
- W2038963573 abstract "Hypertrophic scarring (HSc) is a fibroproliferative disorder of the dermis characterized by erythematous, swollen, and pruritic lesions of healing skin. An increased understanding of the role of TGFβ1 in the development of HSc provides the potential for treating HSc by down-regulating TGFβ1 expression. siRNAs that effectively interfered with TGFβ1 expression were screened. It was concluded that the siRNA-TGFβ1-337 was able to effectively down-regulate TGFβ1 expression in HSc fibroblasts. The effects of siRNA-TGFβ1-337 on cell proliferation, cell cycle, and apoptosis of HSc fibroblasts were investigated. It was shown that it inhibited cell proliferation, arrested cells in the G1 stage of the cell cycle, and induced apoptosis of HSc fibroblasts. The transdermal patch of siRNA-TGFβ1-337 was a combination of siRNA-TGFβ1-337 and a pressure-sensitive adhesive hydrogel. The treatment effects of the transdermal patch were assessed in an animal model established by transplanting human HSc to nude mice. Decreased expression of TGFβ1 was observed with treatment with the transdermal siRNA-TGFβ1-337 patch. Consequently, the treatment resulted in type I collagen down-regulation and regularly arranged scar fibroblasts being significantly reduced and undergoing apoptosis; the scar size was decreased significantly. Thus, our findings indicate that a transdermal siRNA-TGFβ1-337 patch is a potential treatment for hypertrophic scars." @default.
- W2038963573 created "2016-06-24" @default.
- W2038963573 creator A5023308455 @default.
- W2038963573 creator A5039267816 @default.
- W2038963573 creator A5040330264 @default.
- W2038963573 creator A5041282060 @default.
- W2038963573 creator A5087106274 @default.
- W2038963573 date "2013-06-01" @default.
- W2038963573 modified "2023-10-18" @default.
- W2038963573 title "Transdermal siRNA-TGFβ1-337 patch for hypertrophic scar treatment" @default.
- W2038963573 cites W157368067 @default.
- W2038963573 cites W1886472063 @default.
- W2038963573 cites W1967087287 @default.
- W2038963573 cites W1969512119 @default.
- W2038963573 cites W1976001496 @default.
- W2038963573 cites W1977439384 @default.
- W2038963573 cites W1987822574 @default.
- W2038963573 cites W1988958913 @default.
- W2038963573 cites W1993851092 @default.
- W2038963573 cites W1998065111 @default.
- W2038963573 cites W2000708019 @default.
- W2038963573 cites W2001165552 @default.
- W2038963573 cites W2004121042 @default.
- W2038963573 cites W2014116770 @default.
- W2038963573 cites W2015984374 @default.
- W2038963573 cites W2033932030 @default.
- W2038963573 cites W2036405630 @default.
- W2038963573 cites W2036599259 @default.
- W2038963573 cites W2037942851 @default.
- W2038963573 cites W2050252268 @default.
- W2038963573 cites W2060951386 @default.
- W2038963573 cites W2062199188 @default.
- W2038963573 cites W2063474948 @default.
- W2038963573 cites W2065200502 @default.
- W2038963573 cites W2071787763 @default.
- W2038963573 cites W2075044779 @default.
- W2038963573 cites W2075225107 @default.
- W2038963573 cites W2077389455 @default.
- W2038963573 cites W2079232593 @default.
- W2038963573 cites W2081068301 @default.
- W2038963573 cites W2095025343 @default.
- W2038963573 cites W2103031848 @default.
- W2038963573 cites W2110287258 @default.
- W2038963573 cites W2123550509 @default.
- W2038963573 cites W2136176234 @default.
- W2038963573 cites W2136592357 @default.
- W2038963573 cites W2154568166 @default.
- W2038963573 cites W2335838053 @default.
- W2038963573 cites W2403977974 @default.
- W2038963573 cites W2441700042 @default.
- W2038963573 cites W4255779404 @default.
- W2038963573 cites W4313347678 @default.
- W2038963573 doi "https://doi.org/10.1016/j.matbio.2013.02.004" @default.
- W2038963573 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23474398" @default.
- W2038963573 hasPublicationYear "2013" @default.
- W2038963573 type Work @default.
- W2038963573 sameAs 2038963573 @default.
- W2038963573 citedByCount "26" @default.
- W2038963573 countsByYear W20389635732013 @default.
- W2038963573 countsByYear W20389635732014 @default.
- W2038963573 countsByYear W20389635732015 @default.
- W2038963573 countsByYear W20389635732016 @default.
- W2038963573 countsByYear W20389635732017 @default.
- W2038963573 countsByYear W20389635732018 @default.
- W2038963573 countsByYear W20389635732019 @default.
- W2038963573 countsByYear W20389635732020 @default.
- W2038963573 countsByYear W20389635732021 @default.
- W2038963573 countsByYear W20389635732022 @default.
- W2038963573 countsByYear W20389635732023 @default.
- W2038963573 crossrefType "journal-article" @default.
- W2038963573 hasAuthorship W2038963573A5023308455 @default.
- W2038963573 hasAuthorship W2038963573A5039267816 @default.
- W2038963573 hasAuthorship W2038963573A5040330264 @default.
- W2038963573 hasAuthorship W2038963573A5041282060 @default.
- W2038963573 hasAuthorship W2038963573A5087106274 @default.
- W2038963573 hasConcept C104317684 @default.
- W2038963573 hasConcept C118131993 @default.
- W2038963573 hasConcept C142724271 @default.
- W2038963573 hasConcept C1491633281 @default.
- W2038963573 hasConcept C185592680 @default.
- W2038963573 hasConcept C190283241 @default.
- W2038963573 hasConcept C202751555 @default.
- W2038963573 hasConcept C203014093 @default.
- W2038963573 hasConcept C205679159 @default.
- W2038963573 hasConcept C22615655 @default.
- W2038963573 hasConcept C2777624698 @default.
- W2038963573 hasConcept C2777642821 @default.
- W2038963573 hasConcept C2778005187 @default.
- W2038963573 hasConcept C2778698245 @default.
- W2038963573 hasConcept C2780269544 @default.
- W2038963573 hasConcept C2780381497 @default.
- W2038963573 hasConcept C29537977 @default.
- W2038963573 hasConcept C502942594 @default.
- W2038963573 hasConcept C54009773 @default.
- W2038963573 hasConcept C55493867 @default.
- W2038963573 hasConcept C71924100 @default.
- W2038963573 hasConcept C86803240 @default.
- W2038963573 hasConcept C95444343 @default.