Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038964583> ?p ?o ?g. }
- W2038964583 endingPage "1960" @default.
- W2038964583 startingPage "1952" @default.
- W2038964583 abstract "Thyroid hormone is necessary for cochlear development and auditory function, but the factors that control these processes are poorly understood. Previous evidence indicated that in mice, the serum supply of thyroid hormone is augmented within the cochlea itself by type 2 deiodinase, which amplifies the level of T3, the active form of thyroid hormone, before the onset of hearing. We now report that type 3 deiodinase, a thyroid hormone-inactivating enzyme encoded by Dio3, is expressed in the immature cochlea before type 2 deiodinase. Dio3−/− mice display auditory deficits and accelerated cochlear differentiation, contrasting with the retardation caused by deletion of type 2 deiodinase. The Dio3 mRNA expression pattern in the greater epithelial ridge, stria vascularis, and spiral ganglion partly overlaps with that of thyroid hormone receptor β (TRβ), the T3 receptor that is primarily responsible for auditory development. The proposal that type 3 deiodinase prevents premature stimulation of TRβ was supported by deleting TRβ, which converted the Dio3−/− cochlear phenotype from one of accelerated to one of delayed differentiation. The results indicate a protective role for type 3 deiodinase in hearing. The auditory system illustrates the considerable extent to which tissues can autoregulate their developmental response to thyroid hormone through both type 2 and 3 deiodinases." @default.
- W2038964583 created "2016-06-24" @default.
- W2038964583 creator A5004725003 @default.
- W2038964583 creator A5007304489 @default.
- W2038964583 creator A5012272915 @default.
- W2038964583 creator A5030192169 @default.
- W2038964583 creator A5043021964 @default.
- W2038964583 creator A5044718043 @default.
- W2038964583 creator A5045078986 @default.
- W2038964583 creator A5055291286 @default.
- W2038964583 creator A5063573320 @default.
- W2038964583 date "2008-12-18" @default.
- W2038964583 modified "2023-10-13" @default.
- W2038964583 title "A Protective Role for Type 3 Deiodinase, a Thyroid Hormone-Inactivating Enzyme, in Cochlear Development and Auditory Function" @default.
- W2038964583 cites W1875790325 @default.
- W2038964583 cites W1963806203 @default.
- W2038964583 cites W1968635458 @default.
- W2038964583 cites W1972111689 @default.
- W2038964583 cites W1972651008 @default.
- W2038964583 cites W1974813892 @default.
- W2038964583 cites W1975345061 @default.
- W2038964583 cites W1976800670 @default.
- W2038964583 cites W1979016193 @default.
- W2038964583 cites W1981726511 @default.
- W2038964583 cites W1984620537 @default.
- W2038964583 cites W1988377203 @default.
- W2038964583 cites W1990657576 @default.
- W2038964583 cites W1991570572 @default.
- W2038964583 cites W1995637805 @default.
- W2038964583 cites W1998147443 @default.
- W2038964583 cites W1999425294 @default.
- W2038964583 cites W2000458894 @default.
- W2038964583 cites W2013963477 @default.
- W2038964583 cites W2017632004 @default.
- W2038964583 cites W2024788304 @default.
- W2038964583 cites W2026234549 @default.
- W2038964583 cites W2027531766 @default.
- W2038964583 cites W2037312424 @default.
- W2038964583 cites W2041424556 @default.
- W2038964583 cites W2042451650 @default.
- W2038964583 cites W2045703150 @default.
- W2038964583 cites W2046292900 @default.
- W2038964583 cites W2054387207 @default.
- W2038964583 cites W2056933072 @default.
- W2038964583 cites W2059476662 @default.
- W2038964583 cites W2063595480 @default.
- W2038964583 cites W2065851893 @default.
- W2038964583 cites W2075732656 @default.
- W2038964583 cites W2078712130 @default.
- W2038964583 cites W2101123075 @default.
- W2038964583 cites W2104878795 @default.
- W2038964583 cites W2108759450 @default.
- W2038964583 cites W2109053894 @default.
- W2038964583 cites W2123522152 @default.
- W2038964583 cites W2139370258 @default.
- W2038964583 cites W2142718693 @default.
- W2038964583 cites W2144585207 @default.
- W2038964583 cites W2153664733 @default.
- W2038964583 cites W2154619079 @default.
- W2038964583 cites W2155764555 @default.
- W2038964583 cites W4253140603 @default.
- W2038964583 doi "https://doi.org/10.1210/en.2008-1419" @default.
- W2038964583 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2659284" @default.
- W2038964583 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19095741" @default.
- W2038964583 hasPublicationYear "2008" @default.
- W2038964583 type Work @default.
- W2038964583 sameAs 2038964583 @default.
- W2038964583 citedByCount "136" @default.
- W2038964583 countsByYear W20389645832012 @default.
- W2038964583 countsByYear W20389645832013 @default.
- W2038964583 countsByYear W20389645832014 @default.
- W2038964583 countsByYear W20389645832015 @default.
- W2038964583 countsByYear W20389645832016 @default.
- W2038964583 countsByYear W20389645832017 @default.
- W2038964583 countsByYear W20389645832018 @default.
- W2038964583 countsByYear W20389645832019 @default.
- W2038964583 countsByYear W20389645832020 @default.
- W2038964583 countsByYear W20389645832021 @default.
- W2038964583 countsByYear W20389645832022 @default.
- W2038964583 countsByYear W20389645832023 @default.
- W2038964583 crossrefType "journal-article" @default.
- W2038964583 hasAuthorship W2038964583A5004725003 @default.
- W2038964583 hasAuthorship W2038964583A5007304489 @default.
- W2038964583 hasAuthorship W2038964583A5012272915 @default.
- W2038964583 hasAuthorship W2038964583A5030192169 @default.
- W2038964583 hasAuthorship W2038964583A5043021964 @default.
- W2038964583 hasAuthorship W2038964583A5044718043 @default.
- W2038964583 hasAuthorship W2038964583A5045078986 @default.
- W2038964583 hasAuthorship W2038964583A5055291286 @default.
- W2038964583 hasAuthorship W2038964583A5063573320 @default.
- W2038964583 hasBestOaLocation W20389645831 @default.
- W2038964583 hasConcept C109115496 @default.
- W2038964583 hasConcept C126322002 @default.
- W2038964583 hasConcept C134018914 @default.
- W2038964583 hasConcept C169760540 @default.
- W2038964583 hasConcept C170493617 @default.
- W2038964583 hasConcept C171269688 @default.
- W2038964583 hasConcept C2778288131 @default.