FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038967562> ?p ?o ?g. }

• W2038967562 endingPage "106" @default.
• W2038967562 startingPage "95" @default.
• W2038967562 abstract "Human regulatory T cells (Treg) are able to actively suppress autoreactive immune responses. Phenotypically, they are broadly characterized as CD4+, CD25+, CD127(lo/⁻) and FoxP3+. CD45RA can be used to further differentiate the population into naïve (CD45RA(+)) and induced (CD45RA⁻) Treg. The functional potential of Treg is routinely determined by assessing their ability to suppress T cell function in 3-5day proliferation assays. Since Treg are being explored for therapeutic use, a short-term functional assay could serve as a valuable tool for evaluating the potency of Treg. Therefore, an assay designed to measure Treg suppression of activation marker expression by responder T cells in 7 to 20h has been examined in this report. Using flow cytometry, expression of CD69 and CD154 on T cells, in response to stimulation with CD3/CD28 beads, was used as a measure of activation in the assay. Treg from healthy volunteers were sorted as CD4+CD25+CD127(lo/⁻)CD45RA+ cells with a BD FACSAria™ II. The highly purified Treg were then expanded in vitro and their function was assessed in short term activation marker suppression assays using autologous PBMC as responder cells. The data suggest that this short term suppression assay could be a reliable surrogate for assessing Treg functional potential." @default.
• W2038967562 created "2016-06-24" @default.
• W2038967562 creator A5045150910 @default.
• W2038967562 creator A5065828774 @default.
• W2038967562 creator A5075143481 @default.
• W2038967562 creator A5075604383 @default.
• W2038967562 creator A5088465360 @default.
• W2038967562 date "2011-09-01" @default.
• W2038967562 modified "2023-10-06" @default.
• W2038967562 title "Rapid assessment of in vitro expanded human regulatory T cell function" @default.
• W2038967562 cites W1488156742 @default.
• W2038967562 cites W1552549775 @default.
• W2038967562 cites W1560277370 @default.
• W2038967562 cites W1588694091 @default.
• W2038967562 cites W1813961098 @default.
• W2038967562 cites W2000528832 @default.
• W2038967562 cites W2002726823 @default.
• W2038967562 cites W2005612330 @default.
• W2038967562 cites W2007631222 @default.
• W2038967562 cites W2012729754 @default.
• W2038967562 cites W2026836824 @default.
• W2038967562 cites W2027127671 @default.
• W2038967562 cites W2031468489 @default.
• W2038967562 cites W2033415145 @default.
• W2038967562 cites W2036117709 @default.
• W2038967562 cites W2062142808 @default.
• W2038967562 cites W2067263905 @default.
• W2038967562 cites W2076538320 @default.
• W2038967562 cites W2089304112 @default.
• W2038967562 cites W2095671247 @default.
• W2038967562 cites W2097811455 @default.
• W2038967562 cites W2108685327 @default.
• W2038967562 cites W2122445377 @default.
• W2038967562 cites W2147018917 @default.
• W2038967562 cites W2148245227 @default.
• W2038967562 cites W2151005625 @default.
• W2038967562 cites W2156964052 @default.
• W2038967562 cites W2162261192 @default.
• W2038967562 cites W2168628806 @default.
• W2038967562 cites W2169887956 @default.
• W2038967562 cites W2564152524 @default.
• W2038967562 cites W2792745638 @default.
• W2038967562 cites W4231794920 @default.
• W2038967562 doi "https://doi.org/10.1016/j.jim.2011.07.001" @default.
• W2038967562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21781972" @default.
• W2038967562 hasPublicationYear "2011" @default.
• W2038967562 type Work @default.
• W2038967562 sameAs 2038967562 @default.
• W2038967562 citedByCount "33" @default.
• W2038967562 countsByYear W20389675622013 @default.
• W2038967562 countsByYear W20389675622014 @default.
• W2038967562 countsByYear W20389675622015 @default.
• W2038967562 countsByYear W20389675622016 @default.
• W2038967562 countsByYear W20389675622017 @default.
• W2038967562 countsByYear W20389675622018 @default.
• W2038967562 countsByYear W20389675622019 @default.
• W2038967562 countsByYear W20389675622020 @default.
• W2038967562 countsByYear W20389675622022 @default.
• W2038967562 countsByYear W20389675622023 @default.
• W2038967562 crossrefType "journal-article" @default.
• W2038967562 hasAuthorship W2038967562A5045150910 @default.
• W2038967562 hasAuthorship W2038967562A5065828774 @default.
• W2038967562 hasAuthorship W2038967562A5075143481 @default.
• W2038967562 hasAuthorship W2038967562A5075604383 @default.
• W2038967562 hasAuthorship W2038967562A5088465360 @default.
• W2038967562 hasConcept C123982805 @default.
• W2038967562 hasConcept C148125776 @default.
• W2038967562 hasConcept C153911025 @default.
• W2038967562 hasConcept C154317977 @default.
• W2038967562 hasConcept C202751555 @default.
• W2038967562 hasConcept C203014093 @default.
• W2038967562 hasConcept C2776090121 @default.
• W2038967562 hasConcept C2778296632 @default.
• W2038967562 hasConcept C2779234475 @default.
• W2038967562 hasConcept C2779727006 @default.
• W2038967562 hasConcept C2908647359 @default.
• W2038967562 hasConcept C39347974 @default.
• W2038967562 hasConcept C54355233 @default.
• W2038967562 hasConcept C553184892 @default.
• W2038967562 hasConcept C71924100 @default.
• W2038967562 hasConcept C79484868 @default.
• W2038967562 hasConcept C86803240 @default.
• W2038967562 hasConcept C8891405 @default.
• W2038967562 hasConcept C95444343 @default.
• W2038967562 hasConcept C99454951 @default.
• W2038967562 hasConceptScore W2038967562C123982805 @default.
• W2038967562 hasConceptScore W2038967562C148125776 @default.
• W2038967562 hasConceptScore W2038967562C153911025 @default.
• W2038967562 hasConceptScore W2038967562C154317977 @default.
• W2038967562 hasConceptScore W2038967562C202751555 @default.
• W2038967562 hasConceptScore W2038967562C203014093 @default.
• W2038967562 hasConceptScore W2038967562C2776090121 @default.
• W2038967562 hasConceptScore W2038967562C2778296632 @default.
• W2038967562 hasConceptScore W2038967562C2779234475 @default.
• W2038967562 hasConceptScore W2038967562C2779727006 @default.
• W2038967562 hasConceptScore W2038967562C2908647359 @default.
• W2038967562 hasConceptScore W2038967562C39347974 @default.
• W2038967562 hasConceptScore W2038967562C54355233 @default.

• next