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• W2038976543 endingPage "1005" @default.
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• W2038976543 abstract "T Follicular Helper Cell Differentiation When B cells respond to an infection, they often require help from CD4 + T cells to mount a proper response. It is thought that a subset of CD4 + effector T cells, called T follicular helper cells (T FH ), performs this function. Several subsets of effector CD4 + T cells arise, depending on the type of infection, which have distinct transcriptional programs driving their differentiation. Whether this is also the case for T FH cells has not been clear (see the Perspective by Awasthi and Kuchroo ). Nurieva et al. (p. 1001 , published online 23 July) and Johnston et al. (p. 1006 ; published online 16 July) now demonstrate that the transcription factor Bcl6 is both necessary and sufficient for T FH differentiation and subsequent B cell–mediated immunity, suggesting that it is a master regulator of this lineage. Johnston et al. also show that expression of Bcl6 and the transcription factor, Blimp-1, are reciprocally regulated in T FH cells and that, when ectopically expressed, Blimp-1 inhibits T FH development." @default.
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• W2038976543 date "2009-08-21" @default.
• W2038976543 modified "2023-10-14" @default.
• W2038976543 title "Bcl6 Mediates the Development of T Follicular Helper Cells" @default.
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• W2038976543 doi "https://doi.org/10.1126/science.1176676" @default.
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