FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038987199> ?p ?o ?g. }

• W2038987199 endingPage "36" @default.
• W2038987199 startingPage "27" @default.
• W2038987199 abstract "Cartilage tissue lacks an intrinsic capacity for self-regeneration due to slow matrix turnover, a limited supply of mature chondrocytes and insufficient vasculature. Although cartilage tissue engineering has achieved some success using agarose as a scaffolding material, major challenges of agarose-based cartilage repair, including non-degradability, poor tissue-scaffold integration and limited processing capability, have prompted the search for an alternative biomaterial. In this study, silk fiber-hydrogel composites (SF-silk hydrogels) made from silk microfibers and silk hydrogels were investigated for their potential use as a support material for engineered cartilage. We demonstrated the use of 100% silk-based fiber-hydrogel composite scaffolds for the development of cartilage constructs with properties comparable to those made with agarose. Cartilage constructs with an equilibrium modulus in the native tissue range were fabricated by mimicking the collagen fiber and proteoglycan composite architecture of native cartilage using biocompatible, biodegradable silk fibroin from Bombyx mori. Excellent chondrocyte response was observed on SF-silk hydrogels, and fiber reinforcement resulted in the development of more mechanically robust constructs after 42 days in culture compared to silk hydrogels alone. Thus, we demonstrate the versatility of silk fibroin as a composite scaffolding material for use in cartilage tissue repair to create functional cartilage constructs that overcome the limitations of agarose biomaterials, and provide a much-needed alternative to the agarose standard." @default.
• W2038987199 created "2016-06-24" @default.
• W2038987199 creator A5002249797 @default.
• W2038987199 creator A5004335783 @default.
• W2038987199 creator A5005495165 @default.
• W2038987199 creator A5010048130 @default.
• W2038987199 creator A5014552541 @default.
• W2038987199 creator A5033387227 @default.
• W2038987199 creator A5033561591 @default.
• W2038987199 creator A5044928451 @default.
• W2038987199 creator A5057871048 @default.
• W2038987199 creator A5061556684 @default.
• W2038987199 date "2015-01-01" @default.
• W2038987199 modified "2023-10-14" @default.
• W2038987199 title "Silk microfiber-reinforced silk hydrogel composites for functional cartilage tissue repair" @default.
• W2038987199 cites W1963752447 @default.
• W2038987199 cites W1965904253 @default.
• W2038987199 cites W1969693271 @default.
• W2038987199 cites W1970062218 @default.
• W2038987199 cites W1973233997 @default.
• W2038987199 cites W1974128523 @default.
• W2038987199 cites W1976236115 @default.
• W2038987199 cites W1978619076 @default.
• W2038987199 cites W1979736123 @default.
• W2038987199 cites W1981076043 @default.
• W2038987199 cites W1988510537 @default.
• W2038987199 cites W1989940626 @default.
• W2038987199 cites W1992739919 @default.
• W2038987199 cites W1995915070 @default.
• W2038987199 cites W1998157485 @default.
• W2038987199 cites W2002920513 @default.
• W2038987199 cites W2003847663 @default.
• W2038987199 cites W2007469598 @default.
• W2038987199 cites W2009876975 @default.
• W2038987199 cites W2010575269 @default.
• W2038987199 cites W2010742500 @default.
• W2038987199 cites W2015250902 @default.
• W2038987199 cites W2018073995 @default.
• W2038987199 cites W2026198417 @default.
• W2038987199 cites W2026230444 @default.
• W2038987199 cites W2028509138 @default.
• W2038987199 cites W2030585912 @default.
• W2038987199 cites W2032255522 @default.
• W2038987199 cites W2034910904 @default.
• W2038987199 cites W2039918711 @default.
• W2038987199 cites W2047103746 @default.
• W2038987199 cites W2050273631 @default.
• W2038987199 cites W2054630868 @default.
• W2038987199 cites W2060077653 @default.
• W2038987199 cites W2064707228 @default.
• W2038987199 cites W2066288600 @default.
• W2038987199 cites W2066427639 @default.
• W2038987199 cites W2070565156 @default.
• W2038987199 cites W2071706422 @default.
• W2038987199 cites W2077781068 @default.
• W2038987199 cites W2079551440 @default.
• W2038987199 cites W2082181767 @default.
• W2038987199 cites W2082962652 @default.
• W2038987199 cites W2083559588 @default.
• W2038987199 cites W2085711413 @default.
• W2038987199 cites W2087331036 @default.
• W2038987199 cites W2088998471 @default.
• W2038987199 cites W2095505123 @default.
• W2038987199 cites W2098298726 @default.
• W2038987199 cites W2109464227 @default.
• W2038987199 cites W2114302992 @default.
• W2038987199 cites W2116764640 @default.
• W2038987199 cites W2121275713 @default.
• W2038987199 cites W2136194086 @default.
• W2038987199 cites W2136729993 @default.
• W2038987199 cites W2157134073 @default.
• W2038987199 cites W2157908104 @default.
• W2038987199 cites W2159468893 @default.
• W2038987199 cites W2172710605 @default.
• W2038987199 doi "https://doi.org/10.1016/j.actbio.2014.09.032" @default.
• W2038987199 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4256092" @default.
• W2038987199 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25281788" @default.
• W2038987199 hasPublicationYear "2015" @default.
• W2038987199 type Work @default.
• W2038987199 sameAs 2038987199 @default.
• W2038987199 citedByCount "200" @default.
• W2038987199 countsByYear W20389871992015 @default.
• W2038987199 countsByYear W20389871992016 @default.
• W2038987199 countsByYear W20389871992017 @default.
• W2038987199 countsByYear W20389871992018 @default.
• W2038987199 countsByYear W20389871992019 @default.
• W2038987199 countsByYear W20389871992020 @default.
• W2038987199 countsByYear W20389871992021 @default.
• W2038987199 countsByYear W20389871992022 @default.
• W2038987199 countsByYear W20389871992023 @default.
• W2038987199 crossrefType "journal-article" @default.
• W2038987199 hasAuthorship W2038987199A5002249797 @default.
• W2038987199 hasAuthorship W2038987199A5004335783 @default.
• W2038987199 hasAuthorship W2038987199A5005495165 @default.
• W2038987199 hasAuthorship W2038987199A5010048130 @default.
• W2038987199 hasAuthorship W2038987199A5014552541 @default.
• W2038987199 hasAuthorship W2038987199A5033387227 @default.
• W2038987199 hasAuthorship W2038987199A5033561591 @default.

• next