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• W2038992843 abstract "A murine macrophage cell line, J774, expresses high levels of the enzyme nitric oxide synthase (NOS) and produces large amounts of nitric oxide (NO) when activated with recombinant interferon (IFN)-γ and a low concentration of LPS (10ng/ml). Both the expression of NOS and the production of NO were inhibited by recombinant IL-10 in a dose-dependent manner. The inhibition was effective only when the cells were pretreated with IL-10; addition of IL-10 at the same time or after IFN-γ activation was without effect. These results demonstrate that IL-10, a product of Th2 (helper T lymphocyte 2) cells, can antagonise the function of IFN-γ, a product of Thl cells, by modulating the mechanism of synthesis of nitric oxide in the macrophages." @default.
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• W2038992843 date "1992-02-01" @default.
• W2038992843 modified "2023-10-16" @default.
• W2038992843 title "Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-γ in murine macrophages" @default.
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• W2038992843 doi "https://doi.org/10.1016/0006-291x(92)91852-h" @default.
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