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- W2038994844 abstract "Levels of anti-inflammatory extracellular adenosine are controlled by the sequential action of the ectonucleotidases CD39 and CD73, whose expression in CD4+ T cells has been associated with natural regulatory T cells (nTregs). We here show that CD73 expression on activated murine CD4+ T cells is induced by TGF-β independently of Foxp3 expression, operates at the transcriptional level and translates into gain of functional capacity to generate adenosine. In the presence of AMP, CD73 induced by TGF-β generates adenosine able to suppress proliferation of activated CD4+ T cells in vitro. These effects are contextual and opposed by proinflammatory cytokines. CD73 is also upregulated by TGF-β in CD8+ T cells, DCs and macrophages, so providing an amplification mechanism for adenosine generation in tissue microenvironments. Together, these findings expose a novel anti-inflammatory role for TGF-β." @default.
- W2038994844 created "2016-06-24" @default.
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- W2038994844 date "2011-09-06" @default.
- W2038994844 modified "2023-09-25" @default.
- W2038994844 title "Generation of anti-inflammatory adenosine byleukocytes is regulated by TGF-β" @default.
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- W2038994844 doi "https://doi.org/10.1002/eji.201141512" @default.
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