Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038996721> ?p ?o ?g. }
- W2038996721 endingPage "391" @default.
- W2038996721 startingPage "383" @default.
- W2038996721 abstract "Delivery of prophylactic and therapeutic drugs via administration to the mucosal sites of the body may be advantageous for several reasons. However, for peptide and protein drugs being highly charged, bulky and hydrophilic, it may be challenging to cross the mucosal barrier and reach their target site locally in the underlying tissue or after absorption to the systemic circulation. Thus, emerging drug formulation technologies explore a variety of strategies to improve the interaction with both the viscous mucus matrix surface lining the epithelial barrier as well as with the epithelium. However, representative in vitro and in vivo models are needed for the assessment of the delivery potential of such novel delivery systems, e.g. nanoparticles, and for elucidating the detailed mechanisms related to the delivery enhancement. This review focuses on the impact of the mucus layer on mucosal delivery, reviews the state-of-the-art cell culture in vitro models used, and the formulation strategies applied to improve mucosal drug delivery." @default.
- W2038996721 created "2016-06-24" @default.
- W2038996721 creator A5037651942 @default.
- W2038996721 creator A5042180788 @default.
- W2038996721 creator A5064072022 @default.
- W2038996721 creator A5075485219 @default.
- W2038996721 date "2013-01-01" @default.
- W2038996721 modified "2023-10-14" @default.
- W2038996721 title "Mucosal drug delivery: barriers, in vitro models and formulation strategies" @default.
- W2038996721 cites W1496922759 @default.
- W2038996721 cites W1498725963 @default.
- W2038996721 cites W1527851449 @default.
- W2038996721 cites W1542164875 @default.
- W2038996721 cites W1587638772 @default.
- W2038996721 cites W1592701309 @default.
- W2038996721 cites W1964186648 @default.
- W2038996721 cites W1970898345 @default.
- W2038996721 cites W1972523603 @default.
- W2038996721 cites W1972955970 @default.
- W2038996721 cites W1975954165 @default.
- W2038996721 cites W1978129161 @default.
- W2038996721 cites W1983766165 @default.
- W2038996721 cites W1994294415 @default.
- W2038996721 cites W1994638195 @default.
- W2038996721 cites W2000843748 @default.
- W2038996721 cites W2004750142 @default.
- W2038996721 cites W2006520618 @default.
- W2038996721 cites W2006547982 @default.
- W2038996721 cites W2007950027 @default.
- W2038996721 cites W2009473148 @default.
- W2038996721 cites W2010220086 @default.
- W2038996721 cites W2011024089 @default.
- W2038996721 cites W2012045438 @default.
- W2038996721 cites W2017615910 @default.
- W2038996721 cites W2020398834 @default.
- W2038996721 cites W2020768510 @default.
- W2038996721 cites W2021849780 @default.
- W2038996721 cites W2022093158 @default.
- W2038996721 cites W2022132405 @default.
- W2038996721 cites W2022302468 @default.
- W2038996721 cites W2022905205 @default.
- W2038996721 cites W2025463706 @default.
- W2038996721 cites W2026696520 @default.
- W2038996721 cites W2029653463 @default.
- W2038996721 cites W2032999290 @default.
- W2038996721 cites W2034702228 @default.
- W2038996721 cites W2035990801 @default.
- W2038996721 cites W2039167760 @default.
- W2038996721 cites W2040711587 @default.
- W2038996721 cites W2041454039 @default.
- W2038996721 cites W2041456560 @default.
- W2038996721 cites W2043017906 @default.
- W2038996721 cites W2044872933 @default.
- W2038996721 cites W2046497080 @default.
- W2038996721 cites W2049764487 @default.
- W2038996721 cites W2051911729 @default.
- W2038996721 cites W2053559208 @default.
- W2038996721 cites W2054522946 @default.
- W2038996721 cites W2059223510 @default.
- W2038996721 cites W2062932896 @default.
- W2038996721 cites W2063062515 @default.
- W2038996721 cites W2066362724 @default.
- W2038996721 cites W2072125904 @default.
- W2038996721 cites W2073771274 @default.
- W2038996721 cites W2079551453 @default.
- W2038996721 cites W2083187826 @default.
- W2038996721 cites W2087240044 @default.
- W2038996721 cites W2087995038 @default.
- W2038996721 cites W2088119617 @default.
- W2038996721 cites W2096433675 @default.
- W2038996721 cites W2096996795 @default.
- W2038996721 cites W2101594367 @default.
- W2038996721 cites W2105865453 @default.
- W2038996721 cites W2118822263 @default.
- W2038996721 cites W2120950548 @default.
- W2038996721 cites W2126146585 @default.
- W2038996721 cites W2132110161 @default.
- W2038996721 cites W2137777471 @default.
- W2038996721 cites W2141643423 @default.
- W2038996721 cites W2151957316 @default.
- W2038996721 cites W2154855352 @default.
- W2038996721 cites W2162601464 @default.
- W2038996721 cites W2169555148 @default.
- W2038996721 cites W2172521968 @default.
- W2038996721 cites W2914194104 @default.
- W2038996721 cites W2939823076 @default.
- W2038996721 doi "https://doi.org/10.1016/s1773-2247(13)50055-4" @default.
- W2038996721 hasPublicationYear "2013" @default.
- W2038996721 type Work @default.
- W2038996721 sameAs 2038996721 @default.
- W2038996721 citedByCount "42" @default.
- W2038996721 countsByYear W20389967212014 @default.
- W2038996721 countsByYear W20389967212015 @default.
- W2038996721 countsByYear W20389967212016 @default.
- W2038996721 countsByYear W20389967212017 @default.
- W2038996721 countsByYear W20389967212018 @default.
- W2038996721 countsByYear W20389967212019 @default.
- W2038996721 countsByYear W20389967212020 @default.