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- W2038996885 abstract "Background: Cystic fibrosis (CF) occurs in all population groups in South Africa, a middle income country with significant poverty levels. Patients and Methods: Applying Kaplan–Meier statistics to a database of CF patients in the Western Cape province, the overall survival of 217 patients with CF was studied over a 33 year period (1974–2007). The effect of sex and ethnicity on prognosis was explored. Results: Median survival was 20.8 years (25th percentile: 11.6 years). There was no significant difference in survival between males and females (p = 0.5). There was a significant difference in prognosis between white (N = 116) and mixed ethnicity (N = 92) patients (p = 0.0025). There were 17 deaths in infancy (22.6% of all deaths) spread equally across the period. Infant deaths accounted for 2/33 deaths in white patients versus 13/39 deaths in mixed ethnicity patients. Median survival beyond infancy for white patients was 25.8 years versus 20.5 for mixed ethnicity patients (p = 0.007). There was no demonstrable improvement in survival for patients born in the second half of the study period. Conclusions: Median survival is into adulthood in this population. Infant death due to CF is a significant risk in the province. There is an ethic difference in survival that is likely to relate to awareness of CF in different populations and differences in socio-economic status." @default.
- W2038996885 created "2016-06-24" @default.
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- W2038996885 date "2008-06-01" @default.
- W2038996885 modified "2023-09-26" @default.
- W2038996885 title "The prognosis of cystic fibrosis in the Western Cape province of South Africa: a 33 year study" @default.
- W2038996885 doi "https://doi.org/10.1016/s1569-1993(08)60436-1" @default.
- W2038996885 hasPublicationYear "2008" @default.
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