Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039001855> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2039001855 abstract "The role of opiate mechanisms in the development of tolerance and altered susceptibility to seizures after repeated injections of picrotoxin was investigated. Independent groups of rats were pretreated with naloxone (0.3, 1.0, 3.0, and 10.0 mg/kg) or the saline vehicle and then tested for seizures induced by picrotoxin. The procedure was performed on 3 days at 1-week intervals, for a total of 3 testing days. Latencies to different types of seizures, the duration of postseizure immobility, and the number of focal seizure episodes were scored. In the vehicle-treated group, repeated picrotoxin injections led to an increased susceptibility to myoclonic and focal seizures and to decreased duration of postseizure immobility. Naloxone pretreatment significantly decreased the duration of the postseizure akinetic periods in the 1.0- and 10.0-mg/kg groups across all days, suggesting that endogenous opiates are involved in postseizure immobility and that there are interactions between opiate and picrotoxin mechanisms in some seizure-related behaviors. Naloxone did not alter the development of tolerance or sensitivity, indicating that naloxone-insensitive opiate mechanisms or nonopiate mechanisms may be involved in these processes." @default.
- W2039001855 created "2016-06-24" @default.
- W2039001855 creator A5011971424 @default.
- W2039001855 creator A5020402228 @default.
- W2039001855 creator A5087713542 @default.
- W2039001855 date "1993-07-01" @default.
- W2039001855 modified "2023-09-27" @default.
- W2039001855 title "Picrotoxin-induced behavioral tolerance and altered susceptibility to seizures: Effects of naloxone" @default.
- W2039001855 cites W1975161280 @default.
- W2039001855 cites W1982841572 @default.
- W2039001855 cites W1988412488 @default.
- W2039001855 cites W2006241810 @default.
- W2039001855 cites W2012154719 @default.
- W2039001855 cites W2014970846 @default.
- W2039001855 cites W2019884656 @default.
- W2039001855 cites W2043073735 @default.
- W2039001855 cites W2043908343 @default.
- W2039001855 cites W2048777941 @default.
- W2039001855 cites W2052090302 @default.
- W2039001855 cites W2052581573 @default.
- W2039001855 cites W2060592153 @default.
- W2039001855 cites W2084267389 @default.
- W2039001855 cites W2103864711 @default.
- W2039001855 cites W2103946141 @default.
- W2039001855 cites W2149936191 @default.
- W2039001855 cites W2261903952 @default.
- W2039001855 cites W2406870300 @default.
- W2039001855 doi "https://doi.org/10.1016/0091-3057(93)90516-v" @default.
- W2039001855 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8332623" @default.
- W2039001855 hasPublicationYear "1993" @default.
- W2039001855 type Work @default.
- W2039001855 sameAs 2039001855 @default.
- W2039001855 citedByCount "3" @default.
- W2039001855 countsByYear W20390018552013 @default.
- W2039001855 crossrefType "journal-article" @default.
- W2039001855 hasAuthorship W2039001855A5011971424 @default.
- W2039001855 hasAuthorship W2039001855A5020402228 @default.
- W2039001855 hasAuthorship W2039001855A5087713542 @default.
- W2039001855 hasConcept C118552586 @default.
- W2039001855 hasConcept C126322002 @default.
- W2039001855 hasConcept C134018914 @default.
- W2039001855 hasConcept C15744967 @default.
- W2039001855 hasConcept C170493617 @default.
- W2039001855 hasConcept C2775858608 @default.
- W2039001855 hasConcept C2776885963 @default.
- W2039001855 hasConcept C2777397205 @default.
- W2039001855 hasConcept C2778140631 @default.
- W2039001855 hasConcept C2778186239 @default.
- W2039001855 hasConcept C2778460930 @default.
- W2039001855 hasConcept C2778750930 @default.
- W2039001855 hasConcept C2779324764 @default.
- W2039001855 hasConcept C42219234 @default.
- W2039001855 hasConcept C71924100 @default.
- W2039001855 hasConceptScore W2039001855C118552586 @default.
- W2039001855 hasConceptScore W2039001855C126322002 @default.
- W2039001855 hasConceptScore W2039001855C134018914 @default.
- W2039001855 hasConceptScore W2039001855C15744967 @default.
- W2039001855 hasConceptScore W2039001855C170493617 @default.
- W2039001855 hasConceptScore W2039001855C2775858608 @default.
- W2039001855 hasConceptScore W2039001855C2776885963 @default.
- W2039001855 hasConceptScore W2039001855C2777397205 @default.
- W2039001855 hasConceptScore W2039001855C2778140631 @default.
- W2039001855 hasConceptScore W2039001855C2778186239 @default.
- W2039001855 hasConceptScore W2039001855C2778460930 @default.
- W2039001855 hasConceptScore W2039001855C2778750930 @default.
- W2039001855 hasConceptScore W2039001855C2779324764 @default.
- W2039001855 hasConceptScore W2039001855C42219234 @default.
- W2039001855 hasConceptScore W2039001855C71924100 @default.
- W2039001855 hasLocation W20390018551 @default.
- W2039001855 hasLocation W20390018552 @default.
- W2039001855 hasOpenAccess W2039001855 @default.
- W2039001855 hasPrimaryLocation W20390018551 @default.
- W2039001855 hasRelatedWork W105831793 @default.
- W2039001855 hasRelatedWork W1964380232 @default.
- W2039001855 hasRelatedWork W1998359619 @default.
- W2039001855 hasRelatedWork W2005024917 @default.
- W2039001855 hasRelatedWork W2029090481 @default.
- W2039001855 hasRelatedWork W2029679888 @default.
- W2039001855 hasRelatedWork W2031985298 @default.
- W2039001855 hasRelatedWork W2039001855 @default.
- W2039001855 hasRelatedWork W2060367584 @default.
- W2039001855 hasRelatedWork W2168153920 @default.
- W2039001855 isParatext "false" @default.
- W2039001855 isRetracted "false" @default.
- W2039001855 magId "2039001855" @default.
- W2039001855 workType "article" @default.