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- W2039009053 abstract "This chapter provides an overview of antitumor antibiotics. The actinomycins are a group of antibiotics possessing a quinoid-containing phenoxazine chromophore(3-amino-l,8-dimethyl-2-phenoxazone-4,5-dicarboxylic acid) and differ in the amino acid components on two symmetrically substituted polypeptide side chains attached through the carboxylic group. These side chains are necessary for antitumor activity. The new group of ansamycin antibiotics, ansamitocins, having potent antitumor activity was isolated from a fermentation broth of Nocardia sp. No. C-1500s by Higashide et al. Structure of ansamitocin was found to be similar to maytansine and related maytansinoids obtained from plant sources by Kupchan et al. It is very important that the discovery of a microorganism producing ansamitocin opened the way for production of new antitumor ansa macrolides by fermentation, because maytansinoides are only harvested from tropical plants, Maytenus serrata and M. buchananii, and their contents in the plants are extremely low." @default.
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- W2039009053 date "2008-10-01" @default.
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- W2039009053 title "516 POSTER Efficacy of EGFR and IGF-1R antibody therapy is independent of PTEN status in a selection of tumor models" @default.
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