Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039033171> ?p ?o ?g. }
- W2039033171 endingPage "194" @default.
- W2039033171 startingPage "183" @default.
- W2039033171 abstract "This study examined central serotonin disturbance, as reflected by neuroendocrine hormones, among adolescents with major depression. Prolactin, cortisol, and growth hormone were measured following the infusion of a serotonin agonist, meta-chlorophenylpiperazine (mCPP). Twelve (M=6, F=6) medication-free adolescents with major depression (MDD) were compared with 12 (M=6, F=6) matched normal control subjects, ranging in age from 13 to 17 years. Baseline evaluations and a battery of laboratory tests were completed. mCPP, 0.1 mg/kg i. v., was administered in a placebo-controlled design. Analyses of the neuroendocrine hormones revealed that the depressed group had a higher baseline prolactin level and an augmented prolactin response to mCPP challenge than did the control group. The depressed group experienced a sharper baseline-cortisol decline between 08.00 and 11.00 h, and compared to control subjects they displayed an augmented response to the challenge. The depressed group reported more side effects than the control group during saline infusion, but not during mCPP infusion. Findings suggest that depressed adolescents have an elevated baseline prolactin level, and also experience enhanced prolactin and cortisol responses to the serotonergic challenge. These preliminary findings will be confirmed during our ongoing study." @default.
- W2039033171 created "2016-06-24" @default.
- W2039033171 creator A5000207504 @default.
- W2039033171 creator A5021704932 @default.
- W2039033171 creator A5037924335 @default.
- W2039033171 creator A5046010247 @default.
- W2039033171 creator A5048530914 @default.
- W2039033171 creator A5056053431 @default.
- W2039033171 creator A5057216393 @default.
- W2039033171 creator A5082003690 @default.
- W2039033171 date "2000-07-01" @default.
- W2039033171 modified "2023-10-01" @default.
- W2039033171 title "Serotonin dysregulation in adolescents with major depression: hormone response to meta-chlorophenylpiperazine (mCPP) infusion" @default.
- W2039033171 cites W123655207 @default.
- W2039033171 cites W152142219 @default.
- W2039033171 cites W1972359710 @default.
- W2039033171 cites W1974569394 @default.
- W2039033171 cites W1975943241 @default.
- W2039033171 cites W1977866915 @default.
- W2039033171 cites W1977977170 @default.
- W2039033171 cites W1979736169 @default.
- W2039033171 cites W1980993907 @default.
- W2039033171 cites W1981286824 @default.
- W2039033171 cites W1981725027 @default.
- W2039033171 cites W1982852718 @default.
- W2039033171 cites W1991353592 @default.
- W2039033171 cites W1992863880 @default.
- W2039033171 cites W1993015131 @default.
- W2039033171 cites W1996140740 @default.
- W2039033171 cites W2000239724 @default.
- W2039033171 cites W2015055216 @default.
- W2039033171 cites W2019679136 @default.
- W2039033171 cites W2021634787 @default.
- W2039033171 cites W2027107708 @default.
- W2039033171 cites W2032394400 @default.
- W2039033171 cites W2044323467 @default.
- W2039033171 cites W2049442316 @default.
- W2039033171 cites W2060355882 @default.
- W2039033171 cites W2062320303 @default.
- W2039033171 cites W2067160581 @default.
- W2039033171 cites W2069233085 @default.
- W2039033171 cites W2072329023 @default.
- W2039033171 cites W2077343282 @default.
- W2039033171 cites W2083552193 @default.
- W2039033171 cites W2086432861 @default.
- W2039033171 cites W2088213941 @default.
- W2039033171 cites W2088665444 @default.
- W2039033171 cites W2092895325 @default.
- W2039033171 cites W2102039138 @default.
- W2039033171 cites W2106531784 @default.
- W2039033171 cites W2114613490 @default.
- W2039033171 cites W2119226169 @default.
- W2039033171 cites W2129487001 @default.
- W2039033171 cites W2142286817 @default.
- W2039033171 cites W2165225679 @default.
- W2039033171 cites W2337720952 @default.
- W2039033171 cites W2395625506 @default.
- W2039033171 cites W2416020385 @default.
- W2039033171 cites W2463342811 @default.
- W2039033171 doi "https://doi.org/10.1016/s0165-1781(00)00163-3" @default.
- W2039033171 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10974357" @default.
- W2039033171 hasPublicationYear "2000" @default.
- W2039033171 type Work @default.
- W2039033171 sameAs 2039033171 @default.
- W2039033171 citedByCount "11" @default.
- W2039033171 countsByYear W20390331712012 @default.
- W2039033171 countsByYear W20390331712013 @default.
- W2039033171 countsByYear W20390331712014 @default.
- W2039033171 countsByYear W20390331712017 @default.
- W2039033171 countsByYear W20390331712022 @default.
- W2039033171 crossrefType "journal-article" @default.
- W2039033171 hasAuthorship W2039033171A5000207504 @default.
- W2039033171 hasAuthorship W2039033171A5021704932 @default.
- W2039033171 hasAuthorship W2039033171A5037924335 @default.
- W2039033171 hasAuthorship W2039033171A5046010247 @default.
- W2039033171 hasAuthorship W2039033171A5048530914 @default.
- W2039033171 hasAuthorship W2039033171A5056053431 @default.
- W2039033171 hasAuthorship W2039033171A5057216393 @default.
- W2039033171 hasAuthorship W2039033171A5082003690 @default.
- W2039033171 hasConcept C126322002 @default.
- W2039033171 hasConcept C134018914 @default.
- W2039033171 hasConcept C139719470 @default.
- W2039033171 hasConcept C142724271 @default.
- W2039033171 hasConcept C15744967 @default.
- W2039033171 hasConcept C162324750 @default.
- W2039033171 hasConcept C170493617 @default.
- W2039033171 hasConcept C204787440 @default.
- W2039033171 hasConcept C27081682 @default.
- W2039033171 hasConcept C2775864247 @default.
- W2039033171 hasConcept C2776867660 @default.
- W2039033171 hasConcept C2778709874 @default.
- W2039033171 hasConcept C2778938600 @default.
- W2039033171 hasConcept C2779064019 @default.
- W2039033171 hasConcept C2781210005 @default.
- W2039033171 hasConcept C37000724 @default.
- W2039033171 hasConcept C71315377 @default.
- W2039033171 hasConcept C71924100 @default.
- W2039033171 hasConceptScore W2039033171C126322002 @default.