FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039040810> ?p ?o ?g. }

• W2039040810 endingPage "226" @default.
• W2039040810 startingPage "217" @default.
• W2039040810 abstract "The in vitro effects of α-naphthoflavone on four hepatic mono-oxygenase activities associated with aromatic hydrocarbon responsiveness in the mouse (aryl hydrocarbon hydroxylase, 2-acetylamino-fluorene N-hydroxylase, biphenyl 2-hydroxylase, and biphenyl 4-hydroxylase) were investigated before and after methylcholanthrene treatment of C57BL/6N and DBA/2N mice, rats, hamsters, guinea pigs and rabbits. The electrophoretic pattern of cytochrome P-450 subunits and reduced CO-hemoprotein difference spectra of the microsomal fractions were also studied. Pretreatment of animals with methylcholanthrene caused: (1) a 1.5 to 2 mm hypsochromic shift in the Soret peak of the reduced hemoprotein-CO complexes in liver microsomes from a C57BL/6N mouse, rat, hamster and rabbit; a 0.5-nm hypsochromic shift in the guinea pig and no shift in the DBA/2N mouse; and (2) an increase in cytochrome P-450 apoproteins of the following molecular weights on sodium dodecyl sulfate-polyaerylamide gel electrophoresis: 54,000 and 55,000 in the C57BL/6N mouse; 48,000, 54,000 and 55,000 in the rat; 49,000 and 54,000 in the hamster; and 54,000 and 57,000 in the rabbit; a small increase in the 54,000 band was seen in the DBA/2N mouse and no increase in the guinea pig. In vitro addition of α-naphthoflavone selectively inhibited all four mono-oxygenase activities from the methylcholanthrene-treated C57BL/6N mouse, rat and hamster; 2-acetylaminofluorene N-hydroxylase and biphenyl 4-hydroxylase activities in the rabbit; and aryl hydrocarbon hydroxylase, 2-acetylaminofluorene N-hydroxylase and biphenyl 4-hydroxylase activities in the guinea pig. The addition of α-naphthoflavone enhanced the activities of aryl hydrocarbon hydroxylase and biphenyl 2-hydroxylase in liver microsomes from both control and methylcholanthrenetreated rabbits, but only biphenyl 2-hydroxylase activity was increased in the guinea pig: the activitity of 2-acetylaminofluorene N-hydroxylase was increased in both control and methylcholan-threne-treated DBA/2M mice, but only in the control C57BL/6N mouse. These data indicate that hepatic cytochrome P-448 is composed of multiple cytochromes, which differ among animal species, each catalyzing different mono-oxygenase activities." @default.
• W2039040810 created "2016-06-24" @default.
• W2039040810 creator A5015143169 @default.
• W2039040810 creator A5049987089 @default.
• W2039040810 creator A5076743084 @default.
• W2039040810 creator A5087862269 @default.
• W2039040810 date "1979-01-01" @default.
• W2039040810 modified "2023-10-03" @default.
• W2039040810 title "Species differences in the substrate specificity of hepatic cytochrome P-448 From polycyclic hydrocarbon-treated animals" @default.
• W2039040810 cites W1483556659 @default.
• W2039040810 cites W1516077580 @default.
• W2039040810 cites W1542420067 @default.
• W2039040810 cites W1542877165 @default.
• W2039040810 cites W1551046532 @default.
• W2039040810 cites W1564893150 @default.
• W2039040810 cites W1576233898 @default.
• W2039040810 cites W1775749144 @default.
• W2039040810 cites W1951469402 @default.
• W2039040810 cites W1969396272 @default.
• W2039040810 cites W1970231230 @default.
• W2039040810 cites W1972460037 @default.
• W2039040810 cites W1982386536 @default.
• W2039040810 cites W1989852001 @default.
• W2039040810 cites W1994800122 @default.
• W2039040810 cites W2002719254 @default.
• W2039040810 cites W2041544891 @default.
• W2039040810 cites W2052119046 @default.
• W2039040810 cites W2081205552 @default.
• W2039040810 cites W2082164718 @default.
• W2039040810 cites W2100837269 @default.
• W2039040810 cites W2402226689 @default.
• W2039040810 cites W300138568 @default.
• W2039040810 doi "https://doi.org/10.1016/0006-2952(79)90507-0" @default.
• W2039040810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/426837" @default.
• W2039040810 hasPublicationYear "1979" @default.
• W2039040810 type Work @default.
• W2039040810 sameAs 2039040810 @default.
• W2039040810 citedByCount "81" @default.
• W2039040810 countsByYear W20390408102022 @default.
• W2039040810 crossrefType "journal-article" @default.
• W2039040810 hasAuthorship W2039040810A5015143169 @default.
• W2039040810 hasAuthorship W2039040810A5049987089 @default.
• W2039040810 hasAuthorship W2039040810A5076743084 @default.
• W2039040810 hasAuthorship W2039040810A5087862269 @default.
• W2039040810 hasConcept C114246631 @default.
• W2039040810 hasConcept C134018914 @default.
• W2039040810 hasConcept C153911025 @default.
• W2039040810 hasConcept C165474305 @default.
• W2039040810 hasConcept C181199279 @default.
• W2039040810 hasConcept C185592680 @default.
• W2039040810 hasConcept C202751555 @default.
• W2039040810 hasConcept C2778575167 @default.
• W2039040810 hasConcept C2778815084 @default.
• W2039040810 hasConcept C2780303067 @default.
• W2039040810 hasConcept C2780768313 @default.
• W2039040810 hasConcept C526171541 @default.
• W2039040810 hasConcept C55493867 @default.
• W2039040810 hasConcept C86803240 @default.
• W2039040810 hasConcept C87644729 @default.
• W2039040810 hasConceptScore W2039040810C114246631 @default.
• W2039040810 hasConceptScore W2039040810C134018914 @default.
• W2039040810 hasConceptScore W2039040810C153911025 @default.
• W2039040810 hasConceptScore W2039040810C165474305 @default.
• W2039040810 hasConceptScore W2039040810C181199279 @default.
• W2039040810 hasConceptScore W2039040810C185592680 @default.
• W2039040810 hasConceptScore W2039040810C202751555 @default.
• W2039040810 hasConceptScore W2039040810C2778575167 @default.
• W2039040810 hasConceptScore W2039040810C2778815084 @default.
• W2039040810 hasConceptScore W2039040810C2780303067 @default.
• W2039040810 hasConceptScore W2039040810C2780768313 @default.
• W2039040810 hasConceptScore W2039040810C526171541 @default.
• W2039040810 hasConceptScore W2039040810C55493867 @default.
• W2039040810 hasConceptScore W2039040810C86803240 @default.
• W2039040810 hasConceptScore W2039040810C87644729 @default.
• W2039040810 hasIssue "2" @default.
• W2039040810 hasLocation W20390408101 @default.
• W2039040810 hasLocation W20390408102 @default.
• W2039040810 hasOpenAccess W2039040810 @default.
• W2039040810 hasPrimaryLocation W20390408101 @default.
• W2039040810 hasRelatedWork W1623627199 @default.
• W2039040810 hasRelatedWork W1852941485 @default.
• W2039040810 hasRelatedWork W1995210880 @default.
• W2039040810 hasRelatedWork W2035768922 @default.
• W2039040810 hasRelatedWork W2046101633 @default.
• W2039040810 hasRelatedWork W2052206119 @default.
• W2039040810 hasRelatedWork W2056093467 @default.
• W2039040810 hasRelatedWork W2088177704 @default.
• W2039040810 hasRelatedWork W2129737849 @default.
• W2039040810 hasRelatedWork W2426078263 @default.
• W2039040810 hasVolume "28" @default.
• W2039040810 isParatext "false" @default.
• W2039040810 isRetracted "false" @default.
• W2039040810 magId "2039040810" @default.
• W2039040810 workType "article" @default.