Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039043864> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2039043864 endingPage "75" @default.
- W2039043864 startingPage "75" @default.
- W2039043864 abstract "Several inhibitors of S-adenosylhomocysteine (AdoHcy) hydrolase have been found to selectively suppress the replication of African swine fever virus (ASFV) in Vero cells. Of the compounds tested, 3-deazaneplanocin A proved to be the most potent and selective inhibitor of ASFV replication. Its selectivity index (SI) was 3000. Then followed 9-(trans-2′,trans-3′-dihydroxycyclopentyl)-3-deazaadenine (SI = 2500), the 4′β-vinyl derivative of 9-(trans-2′,trans-3′-dihydroxycyclopentyl)adenine (SI = 2000), 6′β-fluoroaristeromycin (SI = 1250), 4′,5′-unsaturated 5′-fluoroadenosine (MDL 28842) and 9-(trans-2′,trans-3′-dihydroxycyclopentyl)adenine (SI = 667), 9-(trans-2′,trans-3′-dihydroxycyclopent-4′-enyl)adenine and the 4β-methyl derivative of 9-(trans-2′,trans-3′-dihydroxycyclopentyl)adenine (SI = 400), 9-(trans-2′,trans-3′-dihydroxycyclopent-4′-enyl)-3-deazaadenine (SI = 200). We postulate that the mechanism of anti-ASFV action of these compounds is based on the inhibition of AdoHcy hydrolase, thus resulting in the accumulation of AdoHcy and suppression of methylation reactions needed for viral mRNA maturation." @default.
- W2039043864 created "2016-06-24" @default.
- W2039043864 creator A5015544354 @default.
- W2039043864 creator A5066437821 @default.
- W2039043864 date "1991-04-01" @default.
- W2039043864 modified "2023-10-14" @default.
- W2039043864 title "Aurintricarboxylic acid: An inhibitor of herpes simplex types I and II, vaccinia and African swine fever viruses replication in vero cells" @default.
- W2039043864 doi "https://doi.org/10.1016/0166-3542(91)90145-h" @default.
- W2039043864 hasPublicationYear "1991" @default.
- W2039043864 type Work @default.
- W2039043864 sameAs 2039043864 @default.
- W2039043864 citedByCount "0" @default.
- W2039043864 crossrefType "journal-article" @default.
- W2039043864 hasAuthorship W2039043864A5015544354 @default.
- W2039043864 hasAuthorship W2039043864A5066437821 @default.
- W2039043864 hasConcept C140704245 @default.
- W2039043864 hasConcept C153911025 @default.
- W2039043864 hasConcept C159047783 @default.
- W2039043864 hasConcept C169586020 @default.
- W2039043864 hasConcept C181199279 @default.
- W2039043864 hasConcept C185592680 @default.
- W2039043864 hasConcept C190283241 @default.
- W2039043864 hasConcept C2522874641 @default.
- W2039043864 hasConcept C2776476023 @default.
- W2039043864 hasConcept C2779686868 @default.
- W2039043864 hasConcept C2781196997 @default.
- W2039043864 hasConcept C31573885 @default.
- W2039043864 hasConcept C55493867 @default.
- W2039043864 hasConcept C86803240 @default.
- W2039043864 hasConcept C89138240 @default.
- W2039043864 hasConceptScore W2039043864C140704245 @default.
- W2039043864 hasConceptScore W2039043864C153911025 @default.
- W2039043864 hasConceptScore W2039043864C159047783 @default.
- W2039043864 hasConceptScore W2039043864C169586020 @default.
- W2039043864 hasConceptScore W2039043864C181199279 @default.
- W2039043864 hasConceptScore W2039043864C185592680 @default.
- W2039043864 hasConceptScore W2039043864C190283241 @default.
- W2039043864 hasConceptScore W2039043864C2522874641 @default.
- W2039043864 hasConceptScore W2039043864C2776476023 @default.
- W2039043864 hasConceptScore W2039043864C2779686868 @default.
- W2039043864 hasConceptScore W2039043864C2781196997 @default.
- W2039043864 hasConceptScore W2039043864C31573885 @default.
- W2039043864 hasConceptScore W2039043864C55493867 @default.
- W2039043864 hasConceptScore W2039043864C86803240 @default.
- W2039043864 hasConceptScore W2039043864C89138240 @default.
- W2039043864 hasLocation W20390438641 @default.
- W2039043864 hasOpenAccess W2039043864 @default.
- W2039043864 hasPrimaryLocation W20390438641 @default.
- W2039043864 hasRelatedWork W1736186603 @default.
- W2039043864 hasRelatedWork W1979414005 @default.
- W2039043864 hasRelatedWork W2040999715 @default.
- W2039043864 hasRelatedWork W2055706740 @default.
- W2039043864 hasRelatedWork W2070257746 @default.
- W2039043864 hasRelatedWork W2084148077 @default.
- W2039043864 hasRelatedWork W2125365865 @default.
- W2039043864 hasRelatedWork W2162468440 @default.
- W2039043864 hasRelatedWork W2487426406 @default.
- W2039043864 hasRelatedWork W4220788934 @default.
- W2039043864 hasVolume "15" @default.
- W2039043864 isParatext "false" @default.
- W2039043864 isRetracted "false" @default.
- W2039043864 magId "2039043864" @default.
- W2039043864 workType "article" @default.