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- W2039051004 abstract "Objective: This study examined the relative merits of different ultrasonic beams and exposure modalities for treating ocular melanomas. Methods: Simulations were conducted to evaluate temperature patterns and lesion shapes induced by intense-ultrasound treatment of ocular tumors. In-vitro insonification experiments were conducted in bovine lenses. Results: Simulated hyperthermia exposures did not effectively treat tumor margins because of thermal conduction into nearby fluid-like media. Standard high-intensity focused beams produced narrow lesions during 2-s exposures. A high-intensity, multi-lobed beam, produced by a transducer with strip electrodes, generated asymmetric lesions with a single large dimension; this lesion shape could expedite the production of lesion matrices within large tumors. In-vitro cataract shapes were consistent with simulation results for focused high-intensity beams. Conclusions: Thermal conduction and perfusion can cause underheating of tumor margins during hyperthermia unless special beam designs are used. The strip-electrode transducer configuration promises to expedite treatment of extended tumor volumes." @default.
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- W2039051004 date "1999-03-01" @default.
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- W2039051004 title "A comparison of ultrasonic beams for thermal treatment of ocular tumors" @default.
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- W2039051004 doi "https://doi.org/10.1016/s0929-8266(99)00011-7" @default.
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