Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039053313> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2039053313 endingPage "1319" @default.
- W2039053313 startingPage "1313" @default.
- W2039053313 abstract "We sought to test the hypotheses that closely related alcohols would have effects on GABAA receptor function that were not predicted by differences in lipid solubility, and that the subunit structure of the GABAA receptor would significantly affect the actions of different alcohols. Cloned subunits of human GABAA receptors were expressed in Xenopus oocytes, and two-electrode voltage-clamp recording was used to quantify the membrane current response to GABA in the presence and absence of different alcohols. 1-Butanol and 2-butanol differentially potentiated the response to 20 microM GABA in oocytes expressing the alpha 1 beta 2 gamma 2L and alpha 2 beta 2 gamma 2L receptor isoforms. In the alpha 1 beta 2 gamma 2L receptor construct, 1-butanol was more potent than 2-butanol to potentiate GABAA receptor function, but 2-butanol had a greater efficacy. In the alpha 2 beta 2 gamma 2L receptor construct, 1-butanol and 2-butanol were equipotent, but 2-butanol again had a greater efficacy. In the alpha 2 beta 2 receptor construct, both 1-butanol and 2-butanol produced large potentiations of the current response to 3 microM GABA. The efficacy for butanol potentiation of GABA responses in the absence of a gamma 2L subunit was greater, but the potency was greatly reduced. Low concentrations (20 mM) of ethanol potentiated GABA responses in the alpha 1 beta 2 gamma 2L receptor construct. Ethanol potentiation of GABAA receptor function was completely blocked by the benzodiazepine receptor partial inverse agonist RO15-4513 at a concentration (0.5 microM) that did not alter the control GABA response. In contrast, RO15-4513 did not block potentiation of GABAA receptor activity induced by n-propanol, 1-butanol, 2-butanol, 1-heptanol, or propofol (2,6-diisopropylphenol). These results suggest that alcohols have specific interactions with GABAA receptors, and that ethanol may have unique effects not shared by other longer chain alcohols." @default.
- W2039053313 created "2016-06-24" @default.
- W2039053313 creator A5013868015 @default.
- W2039053313 creator A5033280558 @default.
- W2039053313 creator A5081440688 @default.
- W2039053313 date "1996-10-01" @default.
- W2039053313 modified "2023-09-27" @default.
- W2039053313 title "Modulation of GABAA Receptor Function by Alcohols: Effects of Subunit Composition and Differential Effects of Ethanol" @default.
- W2039053313 cites W1965369787 @default.
- W2039053313 cites W1973984294 @default.
- W2039053313 cites W1986457041 @default.
- W2039053313 cites W1989046299 @default.
- W2039053313 cites W1995130008 @default.
- W2039053313 cites W1996033662 @default.
- W2039053313 cites W1996339077 @default.
- W2039053313 cites W2018162918 @default.
- W2039053313 cites W2032526814 @default.
- W2039053313 cites W2061874238 @default.
- W2039053313 cites W2067601118 @default.
- W2039053313 cites W2072614922 @default.
- W2039053313 cites W2078855966 @default.
- W2039053313 cites W2086968601 @default.
- W2039053313 cites W2134232707 @default.
- W2039053313 cites W2160614601 @default.
- W2039053313 cites W4237393322 @default.
- W2039053313 doi "https://doi.org/10.1111/j.1530-0277.1996.tb01128.x" @default.
- W2039053313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8904987" @default.
- W2039053313 hasPublicationYear "1996" @default.
- W2039053313 type Work @default.
- W2039053313 sameAs 2039053313 @default.
- W2039053313 citedByCount "23" @default.
- W2039053313 countsByYear W20390533132013 @default.
- W2039053313 crossrefType "journal-article" @default.
- W2039053313 hasAuthorship W2039053313A5013868015 @default.
- W2039053313 hasAuthorship W2039053313A5033280558 @default.
- W2039053313 hasAuthorship W2039053313A5081440688 @default.
- W2039053313 hasConcept C104292427 @default.
- W2039053313 hasConcept C104317684 @default.
- W2039053313 hasConcept C12554922 @default.
- W2039053313 hasConcept C134018914 @default.
- W2039053313 hasConcept C168258287 @default.
- W2039053313 hasConcept C170493617 @default.
- W2039053313 hasConcept C185592680 @default.
- W2039053313 hasConcept C2777771985 @default.
- W2039053313 hasConcept C2778938600 @default.
- W2039053313 hasConcept C2910882050 @default.
- W2039053313 hasConcept C55493867 @default.
- W2039053313 hasConcept C58732023 @default.
- W2039053313 hasConcept C86803240 @default.
- W2039053313 hasConcept C89951826 @default.
- W2039053313 hasConcept C9224880 @default.
- W2039053313 hasConcept C98274493 @default.
- W2039053313 hasConceptScore W2039053313C104292427 @default.
- W2039053313 hasConceptScore W2039053313C104317684 @default.
- W2039053313 hasConceptScore W2039053313C12554922 @default.
- W2039053313 hasConceptScore W2039053313C134018914 @default.
- W2039053313 hasConceptScore W2039053313C168258287 @default.
- W2039053313 hasConceptScore W2039053313C170493617 @default.
- W2039053313 hasConceptScore W2039053313C185592680 @default.
- W2039053313 hasConceptScore W2039053313C2777771985 @default.
- W2039053313 hasConceptScore W2039053313C2778938600 @default.
- W2039053313 hasConceptScore W2039053313C2910882050 @default.
- W2039053313 hasConceptScore W2039053313C55493867 @default.
- W2039053313 hasConceptScore W2039053313C58732023 @default.
- W2039053313 hasConceptScore W2039053313C86803240 @default.
- W2039053313 hasConceptScore W2039053313C89951826 @default.
- W2039053313 hasConceptScore W2039053313C9224880 @default.
- W2039053313 hasConceptScore W2039053313C98274493 @default.
- W2039053313 hasIssue "7" @default.
- W2039053313 hasLocation W20390533131 @default.
- W2039053313 hasLocation W20390533132 @default.
- W2039053313 hasOpenAccess W2039053313 @default.
- W2039053313 hasPrimaryLocation W20390533131 @default.
- W2039053313 hasRelatedWork W1824609386 @default.
- W2039053313 hasRelatedWork W1975678896 @default.
- W2039053313 hasRelatedWork W1988635841 @default.
- W2039053313 hasRelatedWork W2039053313 @default.
- W2039053313 hasRelatedWork W2068510105 @default.
- W2039053313 hasRelatedWork W2086909289 @default.
- W2039053313 hasRelatedWork W2087011017 @default.
- W2039053313 hasRelatedWork W2202224065 @default.
- W2039053313 hasRelatedWork W2396372558 @default.
- W2039053313 hasRelatedWork W2410053025 @default.
- W2039053313 hasVolume "20" @default.
- W2039053313 isParatext "false" @default.
- W2039053313 isRetracted "false" @default.
- W2039053313 magId "2039053313" @default.
- W2039053313 workType "article" @default.