Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039055217> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2039055217 endingPage "1452" @default.
- W2039055217 startingPage "1443" @default.
- W2039055217 abstract "Objectives:To compare the effects of gemcitabine-based chemotherapy and gemcitabine-free regimens, a meta-analysis of all relevant randomized controlled trials was performed to investigate the improvement in overall response rate (ORR), time to progression (TTP), and overall survival (OS). A subgroup of gemcitabine-based doublet compared with single agent was also analyzed.Methods:The PubMed and Embase databases were searched for relevant publications reporting randomized controlled trials comparing gemcitabine-based chemotherapy and gemcitabine-free regimens between January 1990 and December 2012. Hazard ratios (HRs) with their 95% confidence intervals (CIs), or data for calculating HRs with 95% CI were derived.Results:Nine trials with a total of 2651 patients were included in this meta-analysis. Compared with gemcitabine-free chemotherapy, gemcitabine-based therapy demonstrated no improvement in terms of ORR (HR 1.09, 95% CI 0.73–1.62; P = 0.67), TTP (HR 0.91, 95% CI 0.72–1.15; P = 0.44) and OS (HR 1.05, 95% CI 0.88–1.25; P = 0.60). In a subgroup including patients who received adjuvant chemotherapy containing anthracyclines or taxanes, sub-analysis assessment revealed that gemcitabine-based doublets were superior to monotherapy in ORR (HR 1.64, 95% CI 1.26–2.12; P = 0.0002) and TTP (HR 0.71, 95% CI 0.62–0.81; P < 0.00001), but no benefit was observed for OS (HR 0.90, 95% CI 0.79–1.03; P = 0.14). The rates of grade 3 and 4 anemia (HR 2.02, 95% CI 1.35–3.02; P = 0.006), neutropenia (HR 2.33, 95% CI 1.37–3.63; P = 0.01), and thrombocytopenia (HR 8.31, 95% CI 5.00–13.82; P < 0.0001) were significantly higher in the gemcitabine-based arm.Conclusions:The present study suggests that gemcitabine-based chemotherapy was as effective as gemcitabine-free chemotherapy in patients with metastatic breast cancer with increased hematological toxicity. Subgroup analysis indicated that adding gemcitabine to monotherapy might be more effective." @default.
- W2039055217 created "2016-06-24" @default.
- W2039055217 creator A5044423265 @default.
- W2039055217 creator A5050989901 @default.
- W2039055217 creator A5063378661 @default.
- W2039055217 date "2013-09-04" @default.
- W2039055217 modified "2023-10-11" @default.
- W2039055217 title "Efficacy of gemcitabine-based chemotherapy in metastatic breast cancer: a meta-analysis of randomized controlled trials" @default.
- W2039055217 cites W1566131907 @default.
- W2039055217 cites W1986215651 @default.
- W2039055217 cites W2003469641 @default.
- W2039055217 cites W2013593290 @default.
- W2039055217 cites W2019386582 @default.
- W2039055217 cites W2026859784 @default.
- W2039055217 cites W2048553013 @default.
- W2039055217 cites W2086140322 @default.
- W2039055217 cites W2088095316 @default.
- W2039055217 cites W2088305282 @default.
- W2039055217 cites W2096451984 @default.
- W2039055217 cites W2105960180 @default.
- W2039055217 cites W2124241126 @default.
- W2039055217 cites W2130500303 @default.
- W2039055217 cites W2133176934 @default.
- W2039055217 cites W2143249269 @default.
- W2039055217 cites W2143844247 @default.
- W2039055217 cites W2152673885 @default.
- W2039055217 cites W2159329940 @default.
- W2039055217 cites W2163955011 @default.
- W2039055217 cites W2165354425 @default.
- W2039055217 cites W4234749243 @default.
- W2039055217 doi "https://doi.org/10.1185/03007995.2013.832185" @default.
- W2039055217 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23927481" @default.
- W2039055217 hasPublicationYear "2013" @default.
- W2039055217 type Work @default.
- W2039055217 sameAs 2039055217 @default.
- W2039055217 citedByCount "5" @default.
- W2039055217 countsByYear W20390552172014 @default.
- W2039055217 countsByYear W20390552172015 @default.
- W2039055217 countsByYear W20390552172016 @default.
- W2039055217 countsByYear W20390552172017 @default.
- W2039055217 countsByYear W20390552172018 @default.
- W2039055217 crossrefType "journal-article" @default.
- W2039055217 hasAuthorship W2039055217A5044423265 @default.
- W2039055217 hasAuthorship W2039055217A5050989901 @default.
- W2039055217 hasAuthorship W2039055217A5063378661 @default.
- W2039055217 hasConcept C121608353 @default.
- W2039055217 hasConcept C126322002 @default.
- W2039055217 hasConcept C143998085 @default.
- W2039055217 hasConcept C168563851 @default.
- W2039055217 hasConcept C187960798 @default.
- W2039055217 hasConcept C207103383 @default.
- W2039055217 hasConcept C2776694085 @default.
- W2039055217 hasConcept C2777844706 @default.
- W2039055217 hasConcept C2780258809 @default.
- W2039055217 hasConcept C44249647 @default.
- W2039055217 hasConcept C530470458 @default.
- W2039055217 hasConcept C71924100 @default.
- W2039055217 hasConcept C95190672 @default.
- W2039055217 hasConceptScore W2039055217C121608353 @default.
- W2039055217 hasConceptScore W2039055217C126322002 @default.
- W2039055217 hasConceptScore W2039055217C143998085 @default.
- W2039055217 hasConceptScore W2039055217C168563851 @default.
- W2039055217 hasConceptScore W2039055217C187960798 @default.
- W2039055217 hasConceptScore W2039055217C207103383 @default.
- W2039055217 hasConceptScore W2039055217C2776694085 @default.
- W2039055217 hasConceptScore W2039055217C2777844706 @default.
- W2039055217 hasConceptScore W2039055217C2780258809 @default.
- W2039055217 hasConceptScore W2039055217C44249647 @default.
- W2039055217 hasConceptScore W2039055217C530470458 @default.
- W2039055217 hasConceptScore W2039055217C71924100 @default.
- W2039055217 hasConceptScore W2039055217C95190672 @default.
- W2039055217 hasIssue "11" @default.
- W2039055217 hasLocation W20390552171 @default.
- W2039055217 hasLocation W20390552172 @default.
- W2039055217 hasOpenAccess W2039055217 @default.
- W2039055217 hasPrimaryLocation W20390552171 @default.
- W2039055217 hasRelatedWork W1974995659 @default.
- W2039055217 hasRelatedWork W2047788442 @default.
- W2039055217 hasRelatedWork W2055810949 @default.
- W2039055217 hasRelatedWork W2092961885 @default.
- W2039055217 hasRelatedWork W2132919001 @default.
- W2039055217 hasRelatedWork W2132958436 @default.
- W2039055217 hasRelatedWork W2156576546 @default.
- W2039055217 hasRelatedWork W2343453515 @default.
- W2039055217 hasRelatedWork W3149052091 @default.
- W2039055217 hasRelatedWork W4361824915 @default.
- W2039055217 hasVolume "29" @default.
- W2039055217 isParatext "false" @default.
- W2039055217 isRetracted "false" @default.
- W2039055217 magId "2039055217" @default.
- W2039055217 workType "article" @default.