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- W2039062433 endingPage "262" @default.
- W2039062433 startingPage "245" @default.
- W2039062433 abstract "Alzheimer’s disease (AD) is the most common form of senile dementia. Aggregation of the amyloid-β42 peptide (Aβ42) and tau proteins are pathological hallmarks in AD brains. Accumulating evidence suggests that Aβ42 plays a central role in the pathogenesis of AD, and tau acts downstream of Aβ42 as a modulator of the disease progression. Tau pathology is also observed in frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17) and other related diseases, so called tauopathies. Although most cases are sporadic, genes associated with familial AD and FTDP-17 have been identified, which led to the development of transgenic animal models. Drosophila has been a powerful genetic model system used in many fields of biology, and recently emerges as a model for human neurodegenerative diseases. In this review, we will summarize key features of transgenic Drosophila models of AD and tauopathies and a number of insights into disease mechanisms as well as therapeutic implications gained from these models." @default.
- W2039062433 created "2016-06-24" @default.
- W2039062433 creator A5017043028 @default.
- W2039062433 creator A5027880691 @default.
- W2039062433 date "2009-12-05" @default.
- W2039062433 modified "2023-10-11" @default.
- W2039062433 title "Transgenic Drosophila models of Alzheimer’s disease and tauopathies" @default.
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