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• W2039063312 abstract "Six young horses with combined immunodeficiency were given liver cells intravenously or intraperitoneally and thymuses subcutaneously from equine fetuses ranging from 68 to 110 days of gestational age. Three of four horses given cells from fetuses over 90 days of age developed lesions compatible with graft versus host reactions. One horse given cells from an 80-day fetus developed mitogen-responsive lymphocytes, synthesized immunoglobulins of the four major equine classes, and survived to 11.5 months of age. The sixth foal receiving cells from a 68-day fetus showed no discernable effects from the transplant. Parallel in vitro studies were performed to determine the fetal age at which phytolectin-responsive and mixed lymphocyte culture (MLC)-responsive cells appear in fetal tissues. Phytolectin-responsive cells were present in the thymus from 80 days of age, in peripheral blood from 120 days of age, in mesenteric lymph nodes from 180 days, and in the spleen at 200 days of age. Erratic responses were observed with liver cells and no detectable stimulation was observed with bone marrow cells. MLC-responsive cells were present in the thymus as early as 100 days of gestation. The results of these in vivo and in vitro studies indicate equine fetal liver and thymus cells can be used in combination to partially restore immunological function in a genetically based combined immunodeficiency disorder of horses. Furthermore, cells and tissues from equine fetuses around 80 days of age may be effective in achieving reconstitution without inducing severe graft versus host reactions." @default.
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• W2039063312 date "1979-02-01" @default.
• W2039063312 modified "2023-10-14" @default.
• W2039063312 title "Fetal tissue transplantation for immunotherapy of combined immunodeficiency in horses" @default.
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• W2039063312 doi "https://doi.org/10.1016/0090-1229(79)90012-6" @default.
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