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• W2039064181 abstract "Because prior studies have shown inconsistency between structure-activity relationships for podophyllotoxin derivatives as topoisomerase II inhibitors and cytotoxic agents, eight novel podophyllotoxin analogs were synthesized to further explore the effects of structural variations on both A and D rings on activity. The new compounds contain a 4,5-dimethoxy substituted A ring and opened D-ring variants and were prepared by appropriate functional and stereochemical operations at the methylenedioxy group, C7, C8, and C8'. Four compounds (15, 18, 21 and 22) demonstrated noticeable inhibitory activity against A549, DU145, KB and KBvin tumor cells, and the most active compound 18 showed IC(50) values less than 10 μg/mL." @default.
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• W2039064181 date "2012-07-01" @default.
• W2039064181 modified "2023-09-26" @default.
• W2039064181 title "Synthesis and evaluation of novel podophyllotoxin analogs" @default.
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• W2039064181 doi "https://doi.org/10.1016/j.bmcl.2012.05.033" @default.
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