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• W2039083420 abstract "The production of interleukin-12 (IL-12) and its subunits in response to Salmonella enterica serovar Typhimurium infection in the BALB/c mouse was examined. Unlike wild-type Typhimurium, a plasmidless strain, isolated by curing of the virulence plasmid (pSTV), did not stimulate excess IL-12p40 production. When a Tn 5 tagged pSTV was transferred back to the plasmidless strain, the ability to stimulate IL-12p40 production was restored. However, a strain harbouring another Tn50pSTV failed to stimulate excess IL-12p40 production. This Tn 5 insertion area, located on fragment H3 of pSTV, was designated spf (stimulation of protein forty). The ability to stimulate IL-12p40 production was restored in a partial diploid that carried a wild-type fragment covering the spf site. There is one known gene, repA, a locus, rsk, and two putative ORFs, in the vicinity of the Tn 5 insertion site; however, these are not spf. The precise location of the spf locus is still unknown." @default.
• W2039083420 created "2016-06-24" @default.
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• W2039083420 date "2002-01-01" @default.
• W2039083420 modified "2023-09-25" @default.
• W2039083420 title "Excess production of interleukin-12 subunit p40 stimulated by the virulence plasmid of Salmonella enterica serovar Typhimurium in the early phase of infection in the mouse" @default.
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• W2039083420 doi "https://doi.org/10.1006/mpat.2001.0476" @default.
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