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- W2039092254 abstract "Summary Reasons for performing study Laminitis is a painful disease for which adequate pain management remains a challenging and largely unmet medical need. Objectives To investigate plasma concentrations, analgesic and physiological effects of 2 doses of tramadol in horses with chronic laminitis. Study design Nonrandomised trial. Methods Four horses with naturally occurring chronic laminitis received 5 mg/kg bwt and then 10 mg/kg bwt tramadol orally every 12 h for one week with a one‐week washout between. Noninvasive arterial blood pressure, heart and respiratory rates, intestinal sounds and forelimb off‐loading frequency were evaluated before and during treatments. Plasma tramadol and metabolite (M1 and M2) concentrations were measured on predetermined days and times after the morning dosing. Results Forelimb off‐loading frequency decreased significantly with 10 mg/kg bwt (40%, P = 0.02) but not with 5 mg/kg bwt (9%, P = 0.4). Physiological variables did not change significantly with either treatment. For 5 and 10 mg/kg bwt treatments, respectively, individual maximum plasma concentrations (μg/l) ranged from 329 to 728 and 628 to 1330 (tramadol), 12–24 and 32–80 (M1), and 90–157 and 239–362 (M2). Respective median area under the concentration vs. time curves (h μg/l) were 727 and 1426, 33 and 88, 303 and 1003. Conclusions Twice daily oral tramadol at 10 mg/kg bwt may produce analgesic plasma levels in horses with chronic laminitis." @default.
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- W2039092254 date "2015-05-21" @default.
- W2039092254 modified "2023-10-16" @default.
- W2039092254 title "Plasma concentrations, analgesic and physiological assessments in horses with chronic laminitis treated with two doses of oral tramadol" @default.
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- W2039092254 doi "https://doi.org/10.1111/evj.12448" @default.
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