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- W2039094123 abstract "Oligodeoxynucleic acid (21-mer) containing both negatively charged phosphate and positively charged ribonucleic guanidine linkages (RNG/DNA chimera) have been synthesized. DNA binding characteristics and nuclease resistance of RNG/DNA chimeras have been evaluated. Using the bcr-abl oncogene (cause of chronic myeloid leukemia) as a target, the binding of a 21-mer RNG/DNA chimera that includes six RNG’s is more than 103.5 stronger than the binding of 21-mer composed solely of DNA." @default.
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- W2039094123 date "2008-04-01" @default.
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- W2039094123 title "Incorporation of positively charged ribonucleic guanidine linkages into oligodeoxyribonucleotides: Development of potent antisense agents" @default.
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- W2039094123 doi "https://doi.org/10.1016/j.bmcl.2008.02.063" @default.
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