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• W2039100284 abstract "Background The PI3K pathway is known to regulate the transcription of Vascular Endothelial Growth Factor (VEGF) in endothelial and cancer cells. The inhibition of VEGF is the rationale behind the development therapy with anti-angiogenics. We investigated the activation of PI3K pathway, defined as PTEN loss and/or PIK3CA mutations, and the relationship with survival in metastatic breast cancer patients treated with the anti-VEGF monoclonal antibody bevacizumab. Patients and methods : Records for patients with HER2 negative metastatic breast cancer (MBC), treated with bevacizumab from July 2005 to June 2010, and with known PI3K status were reviewed. Univariate and multivariate analysis were performed using SPSS 15.0. Results : A total of 40 patients — 26 with and 14 without PI3K activation — were identified. Median age was 47 years (range 27–79). Median overall survival (OS) was 41.23 months (CI 95%: 27.29 — 55.18) and 66.23 months (CI 95%: 61.04 — 71.42) in patients with and without PI3K activation, respectively (p=0.04). Among patients with PI3K activation, OS was 34.13 months (CI 95%: 22.40 — 45.86) and 43.43 months (CI 95%: 26.9 — 59.97) in cases with PIK3CA mutations and PTEN loss, respectively. As compared to patients without PI3K activation, patients with PI3KCA mutations but not patients with PTEN loss showed a significant worse outcome (p=0.006 and p=0.3, respectively). In the multivariate analysis including grade, hormone receptor and Ki67 status, and total lines of treatment, the activation of PI3K activation proved to be an independent prognostic factor (p=0.03). Conclusions : The activation of the PI3K pathway is significantly associated with decreased OS of MBC patients treated with bevacizumab. Prospective evaluation of PI3K activation on VEGF signaling with differential implication of PI3KCA and PTEN loss is warranted. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P5-13-01." @default.
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• W2039100284 date "2011-12-15" @default.
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• W2039100284 title "P5-13-01: Survival Outcome with Bevacizumab: Activation of the Phosphatidylinositol-3 Kinase (PI3K) Pathway Due to PIK3CA Mutations or PTEN Loss Makes a Difference." @default.
• W2039100284 doi "https://doi.org/10.1158/0008-5472.sabcs11-p5-13-01" @default.
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