Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039101170> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2039101170 abstract "Forty adult patients with chronic asthma completed a 3-month double-blind crossover study to compare the effect of sustained-release theophylline given both as a fixed 300 mg twice daily dose (standard) and an individually titrated dose (titrated) with placebo. Theophylline was given in addition to other usual therapy, inhaled bronchodilators, inhaled steroids and, in 12 patients, oral steroids. The 3-month period was preceded by a run-in phase to determine the dose of theophylline which each subject required to achieve peak serum levels of 12-20 mg/litre and trough levels of 8-12 mg/litre. Doses ranged from 300 mg to 700 mg twice daily. Twenty-one patients needed more than the standard dose to achieve satisfactory serum levels. Patients recorded daily peak flow rates and symptom scores and were seen at monthly intervals to measure lung function, check serum theophylline levels and change treatments, which were given in random order. FEV1 was significantly higher for the whole group after standard (2.11 litres) and titrated (2.15 litres) theophylline therapy than after placebo (1.89 litres), as was FVC, but in the large subgroup whose titrated dose was greater than the standard dose, the FEV1 only improved with the titrated dose. Peak flow measurements at home showed the same pattern. Patients taking oral steroids appeared to derive less benefit from theophylline than others. It is concluded that theophylline can usefully be added as a third-line drug in chronic asthma, but that since half the patients are likely only to benefit from a dose greater than 300 mg twice daily, while the other half may have high serum levels above this dose, it is essential to measure serum levels in order to use the drug effectively and safely." @default.
- W2039101170 created "2016-06-24" @default.
- W2039101170 creator A5011602990 @default.
- W2039101170 creator A5032340907 @default.
- W2039101170 creator A5037574371 @default.
- W2039101170 creator A5054650777 @default.
- W2039101170 creator A5085189826 @default.
- W2039101170 date "1988-01-01" @default.
- W2039101170 modified "2023-10-14" @default.
- W2039101170 title "A double-blind, placebo-controlled comparison of the efficacy of standard and individually titrated doses of theophylline in patients with chronic asthma" @default.
- W2039101170 cites W1982252291 @default.
- W2039101170 cites W1989470873 @default.
- W2039101170 cites W1992868243 @default.
- W2039101170 cites W1996620236 @default.
- W2039101170 cites W1997458957 @default.
- W2039101170 cites W2007998500 @default.
- W2039101170 cites W2014361105 @default.
- W2039101170 cites W2020458001 @default.
- W2039101170 cites W2054399459 @default.
- W2039101170 cites W2060932546 @default.
- W2039101170 cites W2070478670 @default.
- W2039101170 cites W2073920258 @default.
- W2039101170 cites W2075484018 @default.
- W2039101170 cites W2336612646 @default.
- W2039101170 cites W2410974324 @default.
- W2039101170 doi "https://doi.org/10.1016/0007-0971(88)90065-4" @default.
- W2039101170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3073805" @default.
- W2039101170 hasPublicationYear "1988" @default.
- W2039101170 type Work @default.
- W2039101170 sameAs 2039101170 @default.
- W2039101170 citedByCount "2" @default.
- W2039101170 crossrefType "journal-article" @default.
- W2039101170 hasAuthorship W2039101170A5011602990 @default.
- W2039101170 hasAuthorship W2039101170A5032340907 @default.
- W2039101170 hasAuthorship W2039101170A5037574371 @default.
- W2039101170 hasAuthorship W2039101170A5054650777 @default.
- W2039101170 hasAuthorship W2039101170A5085189826 @default.
- W2039101170 hasConcept C126322002 @default.
- W2039101170 hasConcept C142724271 @default.
- W2039101170 hasConcept C176674119 @default.
- W2039101170 hasConcept C204787440 @default.
- W2039101170 hasConcept C27081682 @default.
- W2039101170 hasConcept C2776042228 @default.
- W2039101170 hasConcept C2777288759 @default.
- W2039101170 hasConcept C2778095195 @default.
- W2039101170 hasConcept C2781018748 @default.
- W2039101170 hasConcept C42219234 @default.
- W2039101170 hasConcept C71924100 @default.
- W2039101170 hasConcept C87813604 @default.
- W2039101170 hasConceptScore W2039101170C126322002 @default.
- W2039101170 hasConceptScore W2039101170C142724271 @default.
- W2039101170 hasConceptScore W2039101170C176674119 @default.
- W2039101170 hasConceptScore W2039101170C204787440 @default.
- W2039101170 hasConceptScore W2039101170C27081682 @default.
- W2039101170 hasConceptScore W2039101170C2776042228 @default.
- W2039101170 hasConceptScore W2039101170C2777288759 @default.
- W2039101170 hasConceptScore W2039101170C2778095195 @default.
- W2039101170 hasConceptScore W2039101170C2781018748 @default.
- W2039101170 hasConceptScore W2039101170C42219234 @default.
- W2039101170 hasConceptScore W2039101170C71924100 @default.
- W2039101170 hasConceptScore W2039101170C87813604 @default.
- W2039101170 hasLocation W20391011701 @default.
- W2039101170 hasLocation W20391011702 @default.
- W2039101170 hasOpenAccess W2039101170 @default.
- W2039101170 hasPrimaryLocation W20391011701 @default.
- W2039101170 hasRelatedWork W1783872740 @default.
- W2039101170 hasRelatedWork W1964506673 @default.
- W2039101170 hasRelatedWork W1966374898 @default.
- W2039101170 hasRelatedWork W1966556328 @default.
- W2039101170 hasRelatedWork W2018997574 @default.
- W2039101170 hasRelatedWork W2020365157 @default.
- W2039101170 hasRelatedWork W2109586110 @default.
- W2039101170 hasRelatedWork W2136076889 @default.
- W2039101170 hasRelatedWork W2441215373 @default.
- W2039101170 hasRelatedWork W2342056695 @default.
- W2039101170 isParatext "false" @default.
- W2039101170 isRetracted "false" @default.
- W2039101170 magId "2039101170" @default.
- W2039101170 workType "article" @default.