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- W2039112656 abstract "The purpose of this study was to investigate the pharmacokinetics of R(+)- and S(–)-mepivacaine in 10 male patients after injection of a high dose (731 mg) of racemic R, S-mepivacaine for a combined psoas compartment/sciatic nerve block. Arterial blood samples were taken, and the plasma concentrations of the stereoisomers R(+)- and S(–)-mepivacaine were measured by means of high-performance liquid chromatography (HPLC) with a Chiral AGP column. The S(–) isomer reached higher plasma concentrations than the R(+) isomer. The maximal plasma concentration (Cmax) of R(+) was 1.54 ± 0.34 μg/mL, whereas that of the S(–) isomer was 2.34 ± 0.51 μg/mL (P = 0.00050). The time at which Cmax was reached (Tmax) was identical for both isomers. The area under the plasma concentration-time curve from t = 0 to infinity (AUC∞) of S(–)-mepivacaine was almost double that of R(+)-mepivacaine. The elimination half-life (T1/2) was identical for both isomers (3 h), which means that the calculated total body clearance and the calculated steady-state volume of the distribution of R(+) are, respectively, 1.7 and 1.5 times larger titan that of the S(–) isomer. We conclude that the plasma concentrations of the S(–)-mepivacaine isomer were higher than those of the R(+) isomer because of a smaller volume of distribution and a slower total body clearance." @default.
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- W2039112656 date "1992-07-01" @default.
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- W2039112656 title "Clinical Pharmacokinetics of R(+)-and S(???)-Mepivacaine After High Doses of Racemic Mepivacaine With Epinephrine in the Combined Psoas Compartment/Sciatic Nerve Block" @default.
- W2039112656 doi "https://doi.org/10.1213/00000539-199207000-00014" @default.
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