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- W2039118387 abstract "The general idea is well established that there is an important relationship between the concentration of cholesterol in the blood plasma and the development of atherosclerosis and coronary heart disease. The study of the epidemiology of the disease is as yet only in its crudest beginnings, but two points are agreed. Whenever there is a persistently high level of cholesterol in the blood, there is a tendency toward early and severe atherosclerosis. And whenever there is severe atherosclerosis, there is a high incidence of coronary heart disease. The list of diseases in which occurrence of coronary heart disease is unduly frequent is familiar: diabetes, nephrosis, hypothyroidism, xanthomatosis. These have the common property of being associated with hypercholesteremia. Moreover, in animal experiments whenever it is possible to produce sustained, marked hypercholesteremia, there is eventually development of atherosclerosis. Finally, there is the crucial fact that patients with definite coronary disease tend to" @default.
- W2039118387 created "2016-06-24" @default.
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- W2039118387 date "1951-12-15" @default.
- W2039118387 modified "2023-09-26" @default.
- W2039118387 title "CHOLESTEROL, GIANT MOLECULES, AND ATHEROSCLEROSIS" @default.
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- W2039118387 doi "https://doi.org/10.1001/jama.1951.03670330006003" @default.
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