Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039133791> ?p ?o ?g. }
- W2039133791 endingPage "8835" @default.
- W2039133791 startingPage "8829" @default.
- W2039133791 abstract "Understanding the interaction of (−)-epigallocatechin-3-gallate (EGCG) and lipase is important for understanding EGCG’s inhibition of lipase. In this paper, the interaction of EGCG and porcine lipase was characterized by fluorescence spectroscopy, circular dichroism (CD), isothermal titration calorimetry, and molecular docking. EGCG might act as a noncompetitive pancreatic lipase inhibiter. EGCG bound to lipase with affinity of Ka = 2.70 × 104 L mol–1. Thermodynamic features suggested that the interaction process was spontaneous, with hydrogen bonds and electrostatic force perhaps primarily responsible for the interaction, with 1:1 interaction of lipase and EGCG. CD studies indicated conformation change of lipase on binding to EGCG. Furthermore, docking results supported experimental findings and revealed hydrogen-bonding interaction with Val21, Glu188, and Glu220. This noncovalent bonding between EGCG and lipase alters the molecular conformation of lipase, which decreases the enzyme catalytic activity. This study will help further understand the antiobesity mechanisms of green tea." @default.
- W2039133791 created "2016-06-24" @default.
- W2039133791 creator A5005298628 @default.
- W2039133791 creator A5013017712 @default.
- W2039133791 creator A5027242278 @default.
- W2039133791 creator A5028930572 @default.
- W2039133791 creator A5032813335 @default.
- W2039133791 creator A5050251296 @default.
- W2039133791 creator A5067491298 @default.
- W2039133791 creator A5074742805 @default.
- W2039133791 date "2013-09-06" @default.
- W2039133791 modified "2023-10-17" @default.
- W2039133791 title "Characterization of Binding Interactions of (−)-Epigallocatechin-3-gallate from Green Tea and Lipase" @default.
- W2039133791 cites W1523096910 @default.
- W2039133791 cites W1964253967 @default.
- W2039133791 cites W1965674701 @default.
- W2039133791 cites W1976269461 @default.
- W2039133791 cites W1980706354 @default.
- W2039133791 cites W1988696784 @default.
- W2039133791 cites W1989810100 @default.
- W2039133791 cites W1994142612 @default.
- W2039133791 cites W2008353150 @default.
- W2039133791 cites W2013335354 @default.
- W2039133791 cites W2020069228 @default.
- W2039133791 cites W2020606719 @default.
- W2039133791 cites W2021341863 @default.
- W2039133791 cites W2029794241 @default.
- W2039133791 cites W2033491946 @default.
- W2039133791 cites W2037222355 @default.
- W2039133791 cites W2038314648 @default.
- W2039133791 cites W2045055355 @default.
- W2039133791 cites W2047056023 @default.
- W2039133791 cites W2050523017 @default.
- W2039133791 cites W2052324545 @default.
- W2039133791 cites W2056273882 @default.
- W2039133791 cites W2057687949 @default.
- W2039133791 cites W2064152124 @default.
- W2039133791 cites W2068425317 @default.
- W2039133791 cites W2071692831 @default.
- W2039133791 cites W2074136775 @default.
- W2039133791 cites W2075705506 @default.
- W2039133791 cites W2085052208 @default.
- W2039133791 cites W2091231301 @default.
- W2039133791 cites W2092557507 @default.
- W2039133791 cites W2101063380 @default.
- W2039133791 cites W2108024349 @default.
- W2039133791 cites W2108392416 @default.
- W2039133791 cites W2114057457 @default.
- W2039133791 cites W2115733229 @default.
- W2039133791 cites W2121282652 @default.
- W2039133791 cites W2124045186 @default.
- W2039133791 cites W2140260269 @default.
- W2039133791 cites W2143014690 @default.
- W2039133791 cites W2151605986 @default.
- W2039133791 cites W2169058970 @default.
- W2039133791 cites W2169804397 @default.
- W2039133791 cites W2590966550 @default.
- W2039133791 doi "https://doi.org/10.1021/jf401779z" @default.
- W2039133791 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23971865" @default.
- W2039133791 hasPublicationYear "2013" @default.
- W2039133791 type Work @default.
- W2039133791 sameAs 2039133791 @default.
- W2039133791 citedByCount "77" @default.
- W2039133791 countsByYear W20391337912014 @default.
- W2039133791 countsByYear W20391337912015 @default.
- W2039133791 countsByYear W20391337912016 @default.
- W2039133791 countsByYear W20391337912017 @default.
- W2039133791 countsByYear W20391337912018 @default.
- W2039133791 countsByYear W20391337912019 @default.
- W2039133791 countsByYear W20391337912020 @default.
- W2039133791 countsByYear W20391337912021 @default.
- W2039133791 countsByYear W20391337912022 @default.
- W2039133791 countsByYear W20391337912023 @default.
- W2039133791 crossrefType "journal-article" @default.
- W2039133791 hasAuthorship W2039133791A5005298628 @default.
- W2039133791 hasAuthorship W2039133791A5013017712 @default.
- W2039133791 hasAuthorship W2039133791A5027242278 @default.
- W2039133791 hasAuthorship W2039133791A5028930572 @default.
- W2039133791 hasAuthorship W2039133791A5032813335 @default.
- W2039133791 hasAuthorship W2039133791A5050251296 @default.
- W2039133791 hasAuthorship W2039133791A5067491298 @default.
- W2039133791 hasAuthorship W2039133791A5074742805 @default.
- W2039133791 hasConcept C112887158 @default.
- W2039133791 hasConcept C133571119 @default.
- W2039133791 hasConcept C156911925 @default.
- W2039133791 hasConcept C159110408 @default.
- W2039133791 hasConcept C178790620 @default.
- W2039133791 hasConcept C181199279 @default.
- W2039133791 hasConcept C184866935 @default.
- W2039133791 hasConcept C185592680 @default.
- W2039133791 hasConcept C2777192995 @default.
- W2039133791 hasConcept C2778004101 @default.
- W2039133791 hasConcept C2779697368 @default.
- W2039133791 hasConcept C32909587 @default.
- W2039133791 hasConcept C41685203 @default.
- W2039133791 hasConcept C55493867 @default.
- W2039133791 hasConcept C70899900 @default.
- W2039133791 hasConcept C71240020 @default.