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- W2039139348 abstract "In skeletal msucle, stromal interaction molecule 1 (STIM1) is the calcium sensor of sarcoplasmic reticulum and Orai1 is an extracellular Ca2+-entry channel. These two proteins are known to be components of store-operated Ca2+-entry (SOCE) in skeletal muscle. Here, we examined expression of STIM1 and Orai1 during skeletal muscle cell differentiation. During differentiation of primary mouse skeletal myoblasts to myotubes, Orai1 expression was gradually increased until differentiation day 2 and kept at a certain level on further days of differentiation. STIM1 expression was increased during differentiation. Immunocytochemistry of myoblasts and myotubes with anti-STIM1 and anti-Orai1 antibodies showed that STIM1 and Orai1 were colocalized all over the cells except for nucleus parts during differentiation. These results suggest that SOCE by STIM1 and Orai1 plays a certain role in skeletal muscle differentiation." @default.
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- W2039139348 date "2011-02-01" @default.
- W2039139348 modified "2023-09-29" @default.
- W2039139348 title "Orai1 and STIM1 Expression during Mouse Skeletal Muscle Cell Differentiation" @default.
- W2039139348 doi "https://doi.org/10.1016/j.bpj.2010.12.2459" @default.
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