Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039146594> ?p ?o ?g. }
- W2039146594 endingPage "6999" @default.
- W2039146594 startingPage "6995" @default.
- W2039146594 abstract "Intact bovine fibroblasts, pericytes, and kidney cells manifested significantly less tissue factor procoagulant activity than their disrupted counterparts. Addition of calcium ionophore A23187 rapidly and reversibly enhanced the cell-surface expression of tissue factor in intact cells up to the level achieved by disruption. Inhibitors of calmodulin blocked the ionophore-dependent enhancement of procoagulant activity. Similar kinetic parameters were obtained for factor X hydrolysis by tissue factor-factor VIIa on unperturbed pericytes and phosphatidylcholine vesicles. Increase in Vmax and decrease in apparent Km for this reaction were seen after either disruption or ionophore stimulation of the pericytes. Addition of phosphatidylserine to the reconstituted phospholipid vesicles also increased the Vmax and decreased the apparent Km for factor X hydrolysis. These data agree with the hypothesis that the expression of tissue factor procoagulant activity on cell surfaces is modulated by calcium-mediated changes in the asymmetric distribution of phosphatidylserine in plasma membrane." @default.
- W2039146594 created "2016-06-24" @default.
- W2039146594 creator A5032065685 @default.
- W2039146594 creator A5034002854 @default.
- W2039146594 date "1990-09-01" @default.
- W2039146594 modified "2023-09-25" @default.
- W2039146594 title "Expression of tissue factor procoagulant activity: regulation by cytosolic calcium." @default.
- W2039146594 cites W111894529 @default.
- W2039146594 cites W1234774043 @default.
- W2039146594 cites W129714398 @default.
- W2039146594 cites W1507312029 @default.
- W2039146594 cites W1507458844 @default.
- W2039146594 cites W1530591019 @default.
- W2039146594 cites W1543302782 @default.
- W2039146594 cites W1551068061 @default.
- W2039146594 cites W1585941552 @default.
- W2039146594 cites W174933173 @default.
- W2039146594 cites W178032782 @default.
- W2039146594 cites W1924519659 @default.
- W2039146594 cites W1950361995 @default.
- W2039146594 cites W1960952181 @default.
- W2039146594 cites W1966875441 @default.
- W2039146594 cites W1978533451 @default.
- W2039146594 cites W1983030082 @default.
- W2039146594 cites W1986215971 @default.
- W2039146594 cites W1987183412 @default.
- W2039146594 cites W1992803891 @default.
- W2039146594 cites W1993133875 @default.
- W2039146594 cites W2001127825 @default.
- W2039146594 cites W2001692359 @default.
- W2039146594 cites W2001952162 @default.
- W2039146594 cites W2002621910 @default.
- W2039146594 cites W2019673194 @default.
- W2039146594 cites W2046202266 @default.
- W2039146594 cites W2047848482 @default.
- W2039146594 cites W2049661577 @default.
- W2039146594 cites W2050332662 @default.
- W2039146594 cites W2055612107 @default.
- W2039146594 cites W2061234125 @default.
- W2039146594 cites W2071741411 @default.
- W2039146594 cites W2071782007 @default.
- W2039146594 cites W2105411702 @default.
- W2039146594 cites W2110623508 @default.
- W2039146594 cites W2111574542 @default.
- W2039146594 cites W2123315870 @default.
- W2039146594 cites W2134669421 @default.
- W2039146594 cites W2143666432 @default.
- W2039146594 cites W2149339390 @default.
- W2039146594 cites W2179142653 @default.
- W2039146594 cites W2217705777 @default.
- W2039146594 cites W2318577790 @default.
- W2039146594 cites W2406629693 @default.
- W2039146594 cites W2418555921 @default.
- W2039146594 cites W4250503374 @default.
- W2039146594 cites W70789348 @default.
- W2039146594 cites W975870285 @default.
- W2039146594 doi "https://doi.org/10.1073/pnas.87.18.6995" @default.
- W2039146594 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/54669" @default.
- W2039146594 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2119499" @default.
- W2039146594 hasPublicationYear "1990" @default.
- W2039146594 type Work @default.
- W2039146594 sameAs 2039146594 @default.
- W2039146594 citedByCount "192" @default.
- W2039146594 countsByYear W20391465942012 @default.
- W2039146594 countsByYear W20391465942013 @default.
- W2039146594 countsByYear W20391465942014 @default.
- W2039146594 countsByYear W20391465942015 @default.
- W2039146594 countsByYear W20391465942016 @default.
- W2039146594 countsByYear W20391465942017 @default.
- W2039146594 countsByYear W20391465942018 @default.
- W2039146594 countsByYear W20391465942019 @default.
- W2039146594 countsByYear W20391465942021 @default.
- W2039146594 countsByYear W20391465942022 @default.
- W2039146594 countsByYear W20391465942023 @default.
- W2039146594 crossrefType "journal-article" @default.
- W2039146594 hasAuthorship W2039146594A5032065685 @default.
- W2039146594 hasAuthorship W2039146594A5034002854 @default.
- W2039146594 hasBestOaLocation W20391465941 @default.
- W2039146594 hasConcept C12554922 @default.
- W2039146594 hasConcept C126322002 @default.
- W2039146594 hasConcept C130316041 @default.
- W2039146594 hasConcept C1491633281 @default.
- W2039146594 hasConcept C178790620 @default.
- W2039146594 hasConcept C181199279 @default.
- W2039146594 hasConcept C185592680 @default.
- W2039146594 hasConcept C186738567 @default.
- W2039146594 hasConcept C2778382381 @default.
- W2039146594 hasConcept C2778918659 @default.
- W2039146594 hasConcept C2779014961 @default.
- W2039146594 hasConcept C2779637612 @default.
- W2039146594 hasConcept C29688787 @default.
- W2039146594 hasConcept C41625074 @default.
- W2039146594 hasConcept C519063684 @default.
- W2039146594 hasConcept C55493867 @default.
- W2039146594 hasConcept C71924100 @default.
- W2039146594 hasConcept C86803240 @default.
- W2039146594 hasConcept C88634738 @default.
- W2039146594 hasConcept C95444343 @default.