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• W2039146670 abstract "Abstract Background The best defined costimulators for activation of T lymphocytes are B7‐1 and B7‐2 on antigen presenting cells (APC) that bind to CD28 on T cells. Several studies showed that CD28 is critical for type 2 T helper cells (Th2) inflammation and depends mainly on the interaction of CD28 with B7‐2. Some authors suggested a role for B7‐2 B cells in immunoglobulin E (IgE) synthesis. Objective We decided to study B7‐2/CD28 interaction in atopic dermatitis (AD) and correlations with total and specific IgE, intracellular interleukin 4‐(IL‐4) and interferon‐gamma (IFN‐γ) production during a 1‐month follow‐up. Methods We studied 24 AD children with allergy to cow's milk. Lymphocyte subsets (B7‐2 on B cells, CD28 + on T cells, IL‐4 and IFN‐γ producing T helper cells), total and specific IgE, and IgG4 at days 1 and 30 were also studied. Scoring of atopic dermatitis (SCORAD) significantly decreased. Results CD28 + /CD3 + /CD57 correlated with B7‐2 B cells at days 1 and 30, with IL‐4 and IFN‐γ producing T helper cells at day 1 and with SCORAD at day 30. B7‐2 B cells negatively correlated with IgE at day 30. Percentage of B7‐2 B cells negatively correlated with total and specific IgE at day 30. Conclusion Our results support the importance of CD28/B7 costimulation in AD children and the relation of CD28 with Th1 and Th2 cytokines. However, our results do not confirm the hypothesis about the preferential role of B7‐2 in Th2 activation and IgE synthesis. It could raise a question about B7‐2 blockade efficacy in AD children. Further investigations on B7 family members and their functions could help to distinguish target for more clinically efficient B7/CD28 blockage in AD. Conflicts of interest None declared." @default.
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• W2039146670 date "2009-05-27" @default.
• W2039146670 modified "2023-10-18" @default.
• W2039146670 title "B7-2/CD28 costimulatory pathway in children with atopic dermatitis and its connection with immunoglobulin E, intracellular interleukin-4 and interferon-gamma production by T cells during a 1-month follow-up" @default.
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• W2039146670 doi "https://doi.org/10.1111/j.1468-3083.2009.03133.x" @default.
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