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• W2039156719 startingPage "810" @default.
• W2039156719 abstract "Six diarylheptanoids (1-6) from the stem bark of Alnus hirsuta were investigated for their inhibitory activity against LPS-induced NF-kB activation and NO and TNF-alpha production. Among them, compounds 2, 3, and 6 displayed inhibitory activity against NF-kB activation and NO and TNF-alpha production with IC50 values of 9.2-9.9 microM, 18.2-19.3 microM, and 22.3-23.7 microM, respectively, in RAW264.7 cells. Three active compounds had no significant cytotoxicity in RAW264.7 cells at their effective concentrations. This is the first report of NF-kB-inhibitory activity of these compounds and supports the pharmacological use of A. hirsuta, which has been employed as a herbal medicine for the treatment of inflammatory diseases." @default.
• W2039156719 created "2016-06-24" @default.
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• W2039156719 date "2007-01-01" @default.
• W2039156719 modified "2023-10-16" @default.
• W2039156719 title "Diarylheptanoids from Alnus hirsuta Inhibit the NF-kB Activation and NO and TNF-.ALPHA. Production" @default.
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• W2039156719 doi "https://doi.org/10.1248/bpb.30.810" @default.
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