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- W2039172078 abstract "A variety of evidence supports the concept that the interaction of estradiol with uterine tissue takes place by a two stage mechanism. The hormone associates spontaneously with an extranuclear protein to form an 8S complex, made up of 4S subunits, which possesses a strong affinity for nuclei. In the nucleus a new estradiol-protein complex, extractable as a 5S unit, is formed from the 8S complex by a temperature-dependent process which consumes 8S receptor. The concept of “induced derepression” is proposed to explain how the nuclear transformation of 4S to a 5S estradiol-protein complex might initiate uterine growth." @default.
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- W2039172078 date "1969-04-01" @default.
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- W2039172078 title "Estrogen-binding substances of target tissues" @default.
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- W2039172078 doi "https://doi.org/10.1016/0039-128x(69)90053-1" @default.
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